Cargando…

Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches

Sinuleptolide and its congeners are diterpenes with a norcembranoid skeleton isolated from the soft coral genus Sinularia. These marine metabolites are endowed with relevant biological activities, mainly associated with cancer development. 5-epi-sinuleptolide has been selected as a candidate for tar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morretta, Elva, Esposito, Roberta, Festa, Carmen, Riccio, Raffaele, Casapullo, Agostino, Monti, Maria Chiara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666420/ https://www.ncbi.nlm.nih.gov/pubmed/29027931 http://dx.doi.org/10.3390/md15100312

Ejemplares similares

Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol
por: Cassiano, Chiara, et al.
Publicado: (2019)

Identification of Trombospondin-1 as a Novel Amelogenin Interactor by Functional Proteomics
por: Capolupo, Angela, et al.
Publicado: (2017)

Differential in Gel Electrophoresis (DIGE) Comparative Proteomic Analysis of Macrophages Cell Cultures in Response to Perthamide C Treatment
por: Vilasi, Annalisa, et al.
Publicado: (2013)

Determining the Effect of Pterostilbene on Insulin Secretion Using Chemoproteomics
por: Cassiano, Chiara, et al.
Publicado: (2020)

Label-Free Quantitative Proteomics to Explore the Action Mechanism of the Pharmaceutical-Grade Triticum vulgare Extract in Speeding Up Keratinocyte Healing
por: Morretta, Elva, et al.
Publicado: (2022)

5-epi-Sinuleptolide from Soft Corals of the Genus Sinularia Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK Activity
por: Tsai, Wan-Chi, et al.
Publicado: (2021)

Reactive oxygen species mediate soft corals-derived sinuleptolide-induced antiproliferation and DNA damage in oral cancer cells
por: Chang, Yung-Ting, et al.
Publicado: (2017)

Targeting USP-7 by a Novel Fluorinated 5-Pyrazolyl-Urea Derivative
por: Morretta, Elva, et al.
Publicado: (2023)

Drug affinity-responsive target stability unveils filamins as biological targets for artemetin, an anti-cancer flavonoid
por: Ferraro, Giusy, et al.
Publicado: (2022)

Biological Profile of Two Gentiana lutea L. Metabolites Using Computational Approaches and In Vitro Tests
por: De Vita, Simona, et al.
Publicado: (2021)

Investigating pathological epigenetic aberrations by epi-proteomics
por: Robusti, Giulia, et al.
Publicado: (2022)

Role of Intracellular and Extracellular Annexin A1 in MIA PaCa-2 Spheroids Formation and Drug Sensitivity
por: Novizio, Nunzia, et al.
Publicado: (2022)

Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite
por: Ceccacci, Sara, et al.
Publicado: (2020)

Discovering New G-Quadruplex DNA Catalysts in Enantioselective Sulfoxidation Reaction
por: Festa, Carmen, et al.
Publicado: (2022)

Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated with therapy resistance to anti-PD-1 agents
por: Turiello, Roberta, et al.
Publicado: (2022)

Curcumin Has Beneficial Effects on Lysosomal Alpha-Galactosidase: Potential Implications for the Cure of Fabry Disease
por: Monticelli, Maria, et al.
Publicado: (2023)

Drug Repositioning for Fabry Disease: Acetylsalicylic Acid Potentiates the Stabilization of Lysosomal Alpha-Galactosidase by Pharmacological Chaperones
por: Monticelli, Maria, et al.
Publicado: (2022)

The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs
por: Belvedere, Raffaella, et al.
Publicado: (2021)

Epi‐immunotherapy for cancers: rationales of epi‐drugs in combination with immunotherapy and advances in clinical trials
por: Xu, Yang, et al.
Publicado: (2022)

Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH
por: Marchianò, Silvia, et al.
Publicado: (2023)

Discovering genomics, proteomics, and bioinformatics
por: Campbell, A. Malcolm
Publicado: (2007)

Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy
por: Mazzone, Roberta, et al.
Publicado: (2017)

Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation
por: Carino, Adriana, et al.
Publicado: (2019)

Discovering Biological Psychology
por: Brosnan-Watters, Gayle
Publicado: (2006)

Spatial epi-proteomics enabled by histone post-translational modification analysis from low-abundance clinical samples
por: Noberini, Roberta, et al.
Publicado: (2021)

Identification of Cysteine Ubiquitylation Sites on the Sec23A Protein of the COPII Complex Required for Vesicle Formation from the ER
por: Amodio, Giuseppina, et al.
Publicado: (2017)

An Integrated Genomic, Proteomic, and Immunopeptidomic Approach to Discover Treatment-Induced Neoantigens
por: Olsson, Niclas, et al.
Publicado: (2021)

A Chemical Proteomics Approach to Discover Regulators of Innate Immune Signaling
por: Kurland, Andrew P., et al.
Publicado: (2023)

EpiTracer - an algorithm for identifying epicenters in condition-specific biological networks
por: Sambaturu, Narmada, et al.
Publicado: (2016)

Plakilactones G and H from a marine sponge. Stereochemical determination of highly flexible systems by quantitative NMR-derived interproton distances combined with quantum mechanical calculations of (13)C chemical shifts
por: Di Micco, Simone, et al.
Publicado: (2013)

EpiHRMAssay, in tube and in silico combined approach for the scanning and epityping of heterogeneous DNA methylation
por: Cirilli, Marco, et al.
Publicado: (2017)

Epi-fingerprinting and epi-interventions for improved crop production and food quality
por: Rodríguez López, Carlos M., et al.
Publicado: (2015)

Applications and potentials of nanopore sequencing in the (epi)genome and (epi)transcriptome era
por: Xie, Shangqian, et al.
Publicado: (2021)

Postmortem proteomics to discover biomarkers for forensic PMI estimation
por: Choi, Kyoung-Min, et al.
Publicado: (2019)

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma
por: Di Giorgio, Cristina, et al.
Publicado: (2022)

Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways
por: Rodrigues-Amorim, Daniela, et al.
Publicado: (2019)

Proteomic approach to discover human cancer viruses from formalin-fixed tissues
por: Toptan, Tuna, et al.
Publicado: (2020)

Genetics, epigenetics and pharmaco-(epi)genomics in angiogenesis
por: Buysschaert, Ian, et al.
Publicado: (2008)

Systems biology analysis of the proteomic alterations induced by MPP(+), a Parkinson's disease-related mitochondrial toxin
por: Monti, Chiara, et al.
Publicado: (2015)

Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy
por: Yang, Tianshu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6o1843mm8tbt1r5qbkrerulanq