Cargando…
Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties
The aim of this study was to test the effect of two different morphologies of silver nanoparticles, spheres, and prisms, on their antibacterial properties when coated with poly-L-arginine (poly-Arg) to enhance the interactions with cells. Silver nanoparticle solutions were characterized by UV–visibl...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666461/ https://www.ncbi.nlm.nih.gov/pubmed/28953233 http://dx.doi.org/10.3390/nano7100296 |
_version_ | 1783275318715351040 |
---|---|
author | Tanvir, Fouzia Yaqub, Atif Tanvir, Shazia Anderson, William A. |
author_facet | Tanvir, Fouzia Yaqub, Atif Tanvir, Shazia Anderson, William A. |
author_sort | Tanvir, Fouzia |
collection | PubMed |
description | The aim of this study was to test the effect of two different morphologies of silver nanoparticles, spheres, and prisms, on their antibacterial properties when coated with poly-L-arginine (poly-Arg) to enhance the interactions with cells. Silver nanoparticle solutions were characterized by UV–visible spectroscopy, transmission electron microscopy, dynamic light scattering, zeta potential, as well as antimicrobial tests. These ultimately showed that a prismatic morphology exhibited stronger antimicrobial effects against Escherichia coli, Pseudomonas aeruginosa and Salmonella enterica. The minimum bactericidal concentration was found to be 0.65 μg/mL in the case of a prismatic AgNP-poly-Arg-PVP (silver nanoparticle-poly-L-arginine-polyvinylpyrrolidone) nanocomposite. The anticancer cell activity of the silver nanoparticles was also studied, where the maximum effect against a HeLa cell line was 80% mortality with a prismatic AgNP-poly-Arg-PVP nanocomposite at a concentration of 11 μg/mL. The antimicrobial activity of these silver nanocomposites demonstrates the potential of such coated silver nanoparticles in the area of nano-medicine. |
format | Online Article Text |
id | pubmed-5666461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56664612017-11-09 Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties Tanvir, Fouzia Yaqub, Atif Tanvir, Shazia Anderson, William A. Nanomaterials (Basel) Article The aim of this study was to test the effect of two different morphologies of silver nanoparticles, spheres, and prisms, on their antibacterial properties when coated with poly-L-arginine (poly-Arg) to enhance the interactions with cells. Silver nanoparticle solutions were characterized by UV–visible spectroscopy, transmission electron microscopy, dynamic light scattering, zeta potential, as well as antimicrobial tests. These ultimately showed that a prismatic morphology exhibited stronger antimicrobial effects against Escherichia coli, Pseudomonas aeruginosa and Salmonella enterica. The minimum bactericidal concentration was found to be 0.65 μg/mL in the case of a prismatic AgNP-poly-Arg-PVP (silver nanoparticle-poly-L-arginine-polyvinylpyrrolidone) nanocomposite. The anticancer cell activity of the silver nanoparticles was also studied, where the maximum effect against a HeLa cell line was 80% mortality with a prismatic AgNP-poly-Arg-PVP nanocomposite at a concentration of 11 μg/mL. The antimicrobial activity of these silver nanocomposites demonstrates the potential of such coated silver nanoparticles in the area of nano-medicine. MDPI 2017-09-27 /pmc/articles/PMC5666461/ /pubmed/28953233 http://dx.doi.org/10.3390/nano7100296 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tanvir, Fouzia Yaqub, Atif Tanvir, Shazia Anderson, William A. Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties |
title | Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties |
title_full | Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties |
title_fullStr | Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties |
title_full_unstemmed | Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties |
title_short | Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties |
title_sort | poly-l-arginine coated silver nanoprisms and their anti-bacterial properties |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666461/ https://www.ncbi.nlm.nih.gov/pubmed/28953233 http://dx.doi.org/10.3390/nano7100296 |
work_keys_str_mv | AT tanvirfouzia polylargininecoatedsilvernanoprismsandtheirantibacterialproperties AT yaqubatif polylargininecoatedsilvernanoprismsandtheirantibacterialproperties AT tanvirshazia polylargininecoatedsilvernanoprismsandtheirantibacterialproperties AT andersonwilliama polylargininecoatedsilvernanoprismsandtheirantibacterialproperties |