Cargando…

Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects

Lung cancer is one of the most frequently diagnosed malignancies and is associated with a poor survival rate in the Chinese Han population. Analysis of genetic variants could lead to improvements in prognosis following lung cancer therapy. High-mobility group box 1 protein (HMGB1) is a ubiquitous nu...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Weiwei, Liu, Po-Yi, Yang, Yi-Chen, Chen, Po-Chun, Su, Chen-Ming, Chao, Chia-Chia, Tang, Chih-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666552/
https://www.ncbi.nlm.nih.gov/pubmed/29104475
http://dx.doi.org/10.7150/ijms.20933
_version_ 1783275340823527424
author Hu, Weiwei
Liu, Po-Yi
Yang, Yi-Chen
Chen, Po-Chun
Su, Chen-Ming
Chao, Chia-Chia
Tang, Chih-Hsin
author_facet Hu, Weiwei
Liu, Po-Yi
Yang, Yi-Chen
Chen, Po-Chun
Su, Chen-Ming
Chao, Chia-Chia
Tang, Chih-Hsin
author_sort Hu, Weiwei
collection PubMed
description Lung cancer is one of the most frequently diagnosed malignancies and is associated with a poor survival rate in the Chinese Han population. Analysis of genetic variants could lead to improvements in prognosis following lung cancer therapy. High-mobility group box 1 protein (HMGB1) is a ubiquitous nuclear protein found in eukaryotic cells that participates in several biological functions including immune response, cell survival, apoptosis and cancer development. We investigated the effects of HMGB1 gene polymorphisms on the risk of lung cancer progression in a Chinese Han population. Our sample of 751 participants included 372 patients with lung cancer and 379 healthy controls. Four single-nucleotide polymorphisms (SNPs) of the HMGB1 gene were examined by real-time polymerase chain reaction (RT-PCR). We found that the CT or CC+CT heterozygotes of the HMGB1 rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three HMGB1 SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). The current study is the first to examine the risk factors associated with HMGB1 SNPs in lung cancer development in the Chinese Han population.
format Online
Article
Text
id pubmed-5666552
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-56665522017-11-04 Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects Hu, Weiwei Liu, Po-Yi Yang, Yi-Chen Chen, Po-Chun Su, Chen-Ming Chao, Chia-Chia Tang, Chih-Hsin Int J Med Sci Research Paper Lung cancer is one of the most frequently diagnosed malignancies and is associated with a poor survival rate in the Chinese Han population. Analysis of genetic variants could lead to improvements in prognosis following lung cancer therapy. High-mobility group box 1 protein (HMGB1) is a ubiquitous nuclear protein found in eukaryotic cells that participates in several biological functions including immune response, cell survival, apoptosis and cancer development. We investigated the effects of HMGB1 gene polymorphisms on the risk of lung cancer progression in a Chinese Han population. Our sample of 751 participants included 372 patients with lung cancer and 379 healthy controls. Four single-nucleotide polymorphisms (SNPs) of the HMGB1 gene were examined by real-time polymerase chain reaction (RT-PCR). We found that the CT or CC+CT heterozygotes of the HMGB1 rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three HMGB1 SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). The current study is the first to examine the risk factors associated with HMGB1 SNPs in lung cancer development in the Chinese Han population. Ivyspring International Publisher 2017-09-19 /pmc/articles/PMC5666552/ /pubmed/29104475 http://dx.doi.org/10.7150/ijms.20933 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Hu, Weiwei
Liu, Po-Yi
Yang, Yi-Chen
Chen, Po-Chun
Su, Chen-Ming
Chao, Chia-Chia
Tang, Chih-Hsin
Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects
title Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects
title_full Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects
title_fullStr Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects
title_full_unstemmed Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects
title_short Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects
title_sort association of hmgb1 gene polymorphisms with lung cancer susceptibility and clinical aspects
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666552/
https://www.ncbi.nlm.nih.gov/pubmed/29104475
http://dx.doi.org/10.7150/ijms.20933
work_keys_str_mv AT huweiwei associationofhmgb1genepolymorphismswithlungcancersusceptibilityandclinicalaspects
AT liupoyi associationofhmgb1genepolymorphismswithlungcancersusceptibilityandclinicalaspects
AT yangyichen associationofhmgb1genepolymorphismswithlungcancersusceptibilityandclinicalaspects
AT chenpochun associationofhmgb1genepolymorphismswithlungcancersusceptibilityandclinicalaspects
AT suchenming associationofhmgb1genepolymorphismswithlungcancersusceptibilityandclinicalaspects
AT chaochiachia associationofhmgb1genepolymorphismswithlungcancersusceptibilityandclinicalaspects
AT tangchihhsin associationofhmgb1genepolymorphismswithlungcancersusceptibilityandclinicalaspects