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Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects
Lung cancer is one of the most frequently diagnosed malignancies and is associated with a poor survival rate in the Chinese Han population. Analysis of genetic variants could lead to improvements in prognosis following lung cancer therapy. High-mobility group box 1 protein (HMGB1) is a ubiquitous nu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666552/ https://www.ncbi.nlm.nih.gov/pubmed/29104475 http://dx.doi.org/10.7150/ijms.20933 |
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author | Hu, Weiwei Liu, Po-Yi Yang, Yi-Chen Chen, Po-Chun Su, Chen-Ming Chao, Chia-Chia Tang, Chih-Hsin |
author_facet | Hu, Weiwei Liu, Po-Yi Yang, Yi-Chen Chen, Po-Chun Su, Chen-Ming Chao, Chia-Chia Tang, Chih-Hsin |
author_sort | Hu, Weiwei |
collection | PubMed |
description | Lung cancer is one of the most frequently diagnosed malignancies and is associated with a poor survival rate in the Chinese Han population. Analysis of genetic variants could lead to improvements in prognosis following lung cancer therapy. High-mobility group box 1 protein (HMGB1) is a ubiquitous nuclear protein found in eukaryotic cells that participates in several biological functions including immune response, cell survival, apoptosis and cancer development. We investigated the effects of HMGB1 gene polymorphisms on the risk of lung cancer progression in a Chinese Han population. Our sample of 751 participants included 372 patients with lung cancer and 379 healthy controls. Four single-nucleotide polymorphisms (SNPs) of the HMGB1 gene were examined by real-time polymerase chain reaction (RT-PCR). We found that the CT or CC+CT heterozygotes of the HMGB1 rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three HMGB1 SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). The current study is the first to examine the risk factors associated with HMGB1 SNPs in lung cancer development in the Chinese Han population. |
format | Online Article Text |
id | pubmed-5666552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-56665522017-11-04 Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects Hu, Weiwei Liu, Po-Yi Yang, Yi-Chen Chen, Po-Chun Su, Chen-Ming Chao, Chia-Chia Tang, Chih-Hsin Int J Med Sci Research Paper Lung cancer is one of the most frequently diagnosed malignancies and is associated with a poor survival rate in the Chinese Han population. Analysis of genetic variants could lead to improvements in prognosis following lung cancer therapy. High-mobility group box 1 protein (HMGB1) is a ubiquitous nuclear protein found in eukaryotic cells that participates in several biological functions including immune response, cell survival, apoptosis and cancer development. We investigated the effects of HMGB1 gene polymorphisms on the risk of lung cancer progression in a Chinese Han population. Our sample of 751 participants included 372 patients with lung cancer and 379 healthy controls. Four single-nucleotide polymorphisms (SNPs) of the HMGB1 gene were examined by real-time polymerase chain reaction (RT-PCR). We found that the CT or CC+CT heterozygotes of the HMGB1 rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three HMGB1 SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). The current study is the first to examine the risk factors associated with HMGB1 SNPs in lung cancer development in the Chinese Han population. Ivyspring International Publisher 2017-09-19 /pmc/articles/PMC5666552/ /pubmed/29104475 http://dx.doi.org/10.7150/ijms.20933 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Hu, Weiwei Liu, Po-Yi Yang, Yi-Chen Chen, Po-Chun Su, Chen-Ming Chao, Chia-Chia Tang, Chih-Hsin Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects |
title | Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects |
title_full | Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects |
title_fullStr | Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects |
title_full_unstemmed | Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects |
title_short | Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects |
title_sort | association of hmgb1 gene polymorphisms with lung cancer susceptibility and clinical aspects |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666552/ https://www.ncbi.nlm.nih.gov/pubmed/29104475 http://dx.doi.org/10.7150/ijms.20933 |
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