RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1

Notch signaling is an evolutionarily conserved signal transduction pathway that is essential for metazoan development. Upon ligand binding, the Notch intracellular domain (NOTCH ICD) translocates into the nucleus and forms a complex with the transcription factor RBPJ (also known as CBF1 or CSL) to a...

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Autores principales: Xu, Tao, Park, Sung‐Soo, Giaimo, Benedetto Daniele, Hall, Daniel, Ferrante, Francesca, Ho, Diana M, Hori, Kazuya, Anhezini, Lucas, Ertl, Iris, Bartkuhn, Marek, Zhang, Honglai, Milon, Eléna, Ha, Kimberly, Conlon, Kevin P, Kuick, Rork, Govindarajoo, Brandon, Zhang, Yang, Sun, Yuqing, Dou, Yali, Basrur, Venkatesha, Elenitoba‐Johnson, Kojo SJ, Nesvizhskii, Alexey I, Ceron, Julian, Lee, Cheng‐Yu, Borggrefe, Tilman, Kovall, Rhett A, Rual, Jean‐François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666606/
https://www.ncbi.nlm.nih.gov/pubmed/29030483
http://dx.doi.org/10.15252/embj.201796525

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