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Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis

The Bcl-2 family protein Bim triggers mitochondrial apoptosis. Bim is expressed in nonapoptotic cells at the mitochondrial outer membrane, where it is activated by largely unknown mechanisms. We found that Bim is regulated by formation of large protein complexes containing dynein light chain 1 (DLC1...

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Detalles Bibliográficos
Autores principales:	Singh, Prafull Kumar, Roukounakis, Aristomenis, Frank, Daniel O., Kirschnek, Susanne, Das, Kushal Kumar, Neumann, Simon, Madl, Josef, Römer, Winfried, Zorzin, Carina, Borner, Christoph, Haimovici, Aladin, Garcia-Saez, Ana, Weber, Arnim, Häcker, Georg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666674/ https://www.ncbi.nlm.nih.gov/pubmed/28982759 http://dx.doi.org/10.1101/gad.302497.117

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