Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles

In the treatment of cancer, targeting of anticancer drugs to the tumor microenvironment is highly desirable. Not only does this imply accurate tumor targeting but also minimal drug release en route to the tumor and maximal drug release once there. Here we describe high-loading, “stealth-like” doxoru...

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Detalles Bibliográficos
Autores principales: Kong, Li, Poulcharidis, Dimitrios, Schneider, Gregory F., Campbell, Frederick, Kros, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666715/
https://www.ncbi.nlm.nih.gov/pubmed/28937592
http://dx.doi.org/10.3390/ijms18102033
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author Kong, Li
Poulcharidis, Dimitrios
Schneider, Gregory F.
Campbell, Frederick
Kros, Alexander
author_facet Kong, Li
Poulcharidis, Dimitrios
Schneider, Gregory F.
Campbell, Frederick
Kros, Alexander
author_sort Kong, Li
collection PubMed
description In the treatment of cancer, targeting of anticancer drugs to the tumor microenvironment is highly desirable. Not only does this imply accurate tumor targeting but also minimal drug release en route to the tumor and maximal drug release once there. Here we describe high-loading, “stealth-like” doxorubicin micelles as a pro-drug delivery system, which upon light activation, leads to burst-like doxorbicin release. Through this approach, we show precise spatiotemporal control of doxorubicin delivery to cells in vitro.
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spelling pubmed-56667152017-11-09 Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles Kong, Li Poulcharidis, Dimitrios Schneider, Gregory F. Campbell, Frederick Kros, Alexander Int J Mol Sci Communication In the treatment of cancer, targeting of anticancer drugs to the tumor microenvironment is highly desirable. Not only does this imply accurate tumor targeting but also minimal drug release en route to the tumor and maximal drug release once there. Here we describe high-loading, “stealth-like” doxorubicin micelles as a pro-drug delivery system, which upon light activation, leads to burst-like doxorbicin release. Through this approach, we show precise spatiotemporal control of doxorubicin delivery to cells in vitro. MDPI 2017-09-22 /pmc/articles/PMC5666715/ /pubmed/28937592 http://dx.doi.org/10.3390/ijms18102033 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kong, Li
Poulcharidis, Dimitrios
Schneider, Gregory F.
Campbell, Frederick
Kros, Alexander
Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles
title Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles
title_full Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles
title_fullStr Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles
title_full_unstemmed Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles
title_short Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles
title_sort spatiotemporal control of doxorubicin delivery from “stealth-like” prodrug micelles
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666715/
https://www.ncbi.nlm.nih.gov/pubmed/28937592
http://dx.doi.org/10.3390/ijms18102033
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AT campbellfrederick spatiotemporalcontrolofdoxorubicindeliveryfromstealthlikeprodrugmicelles
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