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Metaplasia in the Stomach—Precursor of Gastric Cancer?
Despite a significant decrease in the incidence of gastric cancer in Western countries over the past century, gastric cancer is still one of the leading causes of cancer-related deaths worldwide. Most human gastric cancers develop after long-term Helicobacter pylori infection via the Correa pathway:...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666745/ https://www.ncbi.nlm.nih.gov/pubmed/28953255 http://dx.doi.org/10.3390/ijms18102063 |
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author | Kinoshita, Hiroto Hayakawa, Yoku Koike, Kazuhiko |
author_facet | Kinoshita, Hiroto Hayakawa, Yoku Koike, Kazuhiko |
author_sort | Kinoshita, Hiroto |
collection | PubMed |
description | Despite a significant decrease in the incidence of gastric cancer in Western countries over the past century, gastric cancer is still one of the leading causes of cancer-related deaths worldwide. Most human gastric cancers develop after long-term Helicobacter pylori infection via the Correa pathway: the progression is from gastritis, atrophy, intestinal metaplasia, dysplasia, to cancer. However, it remains unclear whether metaplasia is a direct precursor of gastric cancer or merely a marker of high cancer risk. Here, we review human studies on the relationship between metaplasia and cancer in the stomach, data from mouse models of metaplasia regarding the mechanism of metaplasia development, and the cellular responses induced by H. pylori infection. |
format | Online Article Text |
id | pubmed-5666745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56667452017-11-09 Metaplasia in the Stomach—Precursor of Gastric Cancer? Kinoshita, Hiroto Hayakawa, Yoku Koike, Kazuhiko Int J Mol Sci Review Despite a significant decrease in the incidence of gastric cancer in Western countries over the past century, gastric cancer is still one of the leading causes of cancer-related deaths worldwide. Most human gastric cancers develop after long-term Helicobacter pylori infection via the Correa pathway: the progression is from gastritis, atrophy, intestinal metaplasia, dysplasia, to cancer. However, it remains unclear whether metaplasia is a direct precursor of gastric cancer or merely a marker of high cancer risk. Here, we review human studies on the relationship between metaplasia and cancer in the stomach, data from mouse models of metaplasia regarding the mechanism of metaplasia development, and the cellular responses induced by H. pylori infection. MDPI 2017-09-27 /pmc/articles/PMC5666745/ /pubmed/28953255 http://dx.doi.org/10.3390/ijms18102063 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kinoshita, Hiroto Hayakawa, Yoku Koike, Kazuhiko Metaplasia in the Stomach—Precursor of Gastric Cancer? |
title | Metaplasia in the Stomach—Precursor of Gastric Cancer? |
title_full | Metaplasia in the Stomach—Precursor of Gastric Cancer? |
title_fullStr | Metaplasia in the Stomach—Precursor of Gastric Cancer? |
title_full_unstemmed | Metaplasia in the Stomach—Precursor of Gastric Cancer? |
title_short | Metaplasia in the Stomach—Precursor of Gastric Cancer? |
title_sort | metaplasia in the stomach—precursor of gastric cancer? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666745/ https://www.ncbi.nlm.nih.gov/pubmed/28953255 http://dx.doi.org/10.3390/ijms18102063 |
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