Achiral Mannich-Base Curcumin Analogs Induce Unfolded Protein Response and Mitochondrial Membrane Depolarization in PANC-1 Cells

Achiral Mannich-type curcumin analogs have been synthetized and assayed for their cytotoxic activity. The anti-proliferative and cytotoxic activity of curcuminoids has been tested on human non-small-cell lung carcinoma (A549), hepatocellular carcinoma (HepG2) and pancreatic cancer cell line (PANC-1)...

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Detalles Bibliográficos
Autores principales: Szebeni, Gábor J., Balázs, Árpád, Madarász, Ildikó, Pócz, Gábor, Ayaydin, Ferhan, Kanizsai, Iván, Fajka-Boja, Roberta, Alföldi, Róbert, Hackler, László, Puskás, László G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666787/
https://www.ncbi.nlm.nih.gov/pubmed/28991167
http://dx.doi.org/10.3390/ijms18102105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666787/
https://www.ncbi.nlm.nih.gov/pubmed/28991167
http://dx.doi.org/10.3390/ijms18102105

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