Cargando…

Rebalancing β-Amyloid-Induced Decrease of ATP Level by Amorphous Nano/Micro Polyphosphate: Suppression of the Neurotoxic Effect of Amyloid β-Protein Fragment 25-35

Morbus Alzheimer neuropathology is characterized by an impaired energy homeostasis of brain tissue. We present an approach towards a potential therapy of Alzheimer disease based on the high-energy polymer inorganic polyphosphate (polyP), which physiologically occurs both in the extracellular and in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Müller, Werner E. G., Wang, Shunfeng, Ackermann, Maximilian, Neufurth, Meik, Steffen, Renate, Mecja, Egherta, Muñoz-Espí, Rafael, Feng, Qingling, Schröder, Heinz C., Wang, Xiaohong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666835/ https://www.ncbi.nlm.nih.gov/pubmed/29035351 http://dx.doi.org/10.3390/ijms18102154

Ejemplares similares

Amorphous, Smart, and Bioinspired Polyphosphate Nano/Microparticles: A Biomaterial for Regeneration and Repair of Osteo-Articular Impairments In-Situ
por: Müller, Werner E. G., et al.
Publicado: (2018)

Morphogenetically-Active Barrier Membrane for Guided Bone Regeneration, Based on Amorphous Polyphosphate
por: Wang, Xiaohong, et al.
Publicado: (2017)

A Novel Biomimetic Approach to Repair Enamel Cracks/Carious Damages and to Reseal Dentinal Tubules by Amorphous Polyphosphate
por: Müller, Werner E. G., et al.
Publicado: (2017)

Self-Healing Properties of Bioinspired Amorphous CaCO(3)/Polyphosphate-Supplemented Cement
por: Tolba, Emad, et al.
Publicado: (2020)

Restoration of Impaired Metabolic Energy Balance (ATP Pool) and Tube Formation Potential of Endothelial Cells under “high glucose”, Diabetic Conditions by the Bioinorganic Polymer Polyphosphate
por: Wang, Xiaohong, et al.
Publicado: (2017)

Uptake of polyphosphate microparticles in vitro (SaOS-2 and HUVEC cells) followed by an increase of the intracellular ATP pool size
por: Müller, Werner E. G., et al.
Publicado: (2017)

Enhancement of Wound Healing in Normal and Diabetic Mice by Topical Application of Amorphous Polyphosphate. Superior Effect of a Host–Guest Composite Material Composed of Collagen (Host) and Polyphosphate (Guest)
por: Müller, Werner E. G., et al.
Publicado: (2017)

Acceleration of Wound Healing through Amorphous Calcium Carbonate, Stabilized with High-Energy Polyphosphate
por: Wang, Shunfeng, et al.
Publicado: (2023)

Inorganic Polyphosphate: Coacervate Formation and Functional Significance in Nanomedical Applications
por: Schröder, Heinz C, et al.
Publicado: (2022)

Polyphosphate Reverses the Toxicity of the Quasi-Enzyme Bleomycin on Alveolar Endothelial Lung Cells In Vitro †
por: Müller, Werner E. G., et al.
Publicado: (2021)

Nanoparticle-directed and ionically forced polyphosphate coacervation: a versatile and reversible core–shell system for drug delivery
por: Müller, Werner E. G., et al.
Publicado: (2020)

Functional importance of coacervation to convert calcium polyphosphate nanoparticles into the physiologically active state
por: Müller, Werner E.G., et al.
Publicado: (2022)

Caged Dexamethasone/Quercetin Nanoparticles, Formed of the Morphogenetic Active Inorganic Polyphosphate, are Strong Inducers of MUC5AC
por: Neufurth, Meik, et al.
Publicado: (2021)

In Situ Polyphosphate Nanoparticle Formation in Hybrid Poly(vinyl alcohol)/Karaya Gum Hydrogels: A Porous Scaffold Inducing Infiltration of Mesenchymal Stem Cells
por: Tolba, Emad, et al.
Publicado: (2018)

The therapeutic potential of inorganic polyphosphate: A versatile physiological polymer to control coronavirus disease (COVID-19)
por: Schepler, Hadrian, et al.
Publicado: (2021)

Acceleration of chronic wound healing by bio-inorganic polyphosphate: In vitro studies and first clinical applications
por: Schepler, Hadrian, et al.
Publicado: (2022)

Morphogenetic (Mucin Expression) as Well as Potential Anti-Corona Viral Activity of the Marine Secondary Metabolite Polyphosphate on A549 Cells
por: Müller, Werner E. G., et al.
Publicado: (2020)

Biomimetic Alginate/Gelatin Cross-Linked Hydrogels Supplemented with Polyphosphate for Wound Healing Applications
por: Wang, Shunfeng, et al.
Publicado: (2020)

The inorganic polymer, polyphosphate, blocks binding of SARS-CoV-2 spike protein to ACE2 receptor at physiological concentrations
por: Neufurth, Meik, et al.
Publicado: (2020)

Transformation of Construction Cement to a Self-Healing Hybrid Binder
por: Müller, Werner E.G., et al.
Publicado: (2019)

Utilization of metabolic energy in treatment of ocular surface disorders: polyphosphate as an energy source for corneal epithelial cell proliferation
por: Gericke, Adrian, et al.
Publicado: (2019)

An unexpected biomaterial against SARS-CoV-2: Bio-polyphosphate blocks binding of the viral spike to the cell receptor
por: Müller, Werner E.G., et al.
Publicado: (2021)

Triple-target stimuli-responsive anti-COVID-19 face mask with physiological virus-inactivating agents
por: Müller, Werner E. G., et al.
Publicado: (2021)

A Peptide That Binds Specifically to the β-Amyloid of Alzheimer's Disease: Selection and Assessment of Anti-β-Amyloid Neurotoxic Effects
por: Wang, Fang, et al.
Publicado: (2011)

Inhibitory Effects of Edaravone in β-Amyloid-Induced Neurotoxicity in Rats
por: He, Feng, et al.
Publicado: (2014)

Neuroprotective effects of statins against amyloid β-induced neurotoxicity
por: Li, Hsin-Hua, et al.
Publicado: (2018)

Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo
por: Sowade, Ramona F., et al.
Publicado: (2017)

A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
por: Cataldi, Rodrigo, et al.
Publicado: (2021)

Nanoscopic insights into the surface conformation of neurotoxic amyloid β oligomers
por: Banchelli, Martina, et al.
Publicado: (2020)

N-terminal Domain of Amyloid-β Impacts Fibrillation and Neurotoxicity
por: Shi, Jing-Ming, et al.
Publicado: (2022)

Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β(1-42)
por: Bate, Clive, et al.
Publicado: (2004)

Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils
por: Ahmed, Mahiuddin, et al.
Publicado: (2010)

Mitochondrial Ferritin Deletion Exacerbates β-Amyloid-Induced Neurotoxicity in Mice
por: Wang, Peina, et al.
Publicado: (2017)

Neuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity
por: Li, Xiao-Hui, et al.
Publicado: (2016)

RRY Inhibits Amyloid-β(1–42) Peptide Aggregation and Neurotoxicity
por: Sun, Xicui, et al.
Publicado: (2021)

Amyloid-β 25-35 Induces Neurotoxicity through the Up-Regulation of Astrocytic System X(c)(−)
por: D’Ezio, Veronica, et al.
Publicado: (2021)

Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid β-Mediated Neurotoxicity
por: Dai, Xueling, et al.
Publicado: (2015)

The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model
por: Tanokashira, Daisuke, et al.
Publicado: (2017)

Experimental study on the neurotoxic effect of β-amyloid on the cytoskeleton of PC12 cells
por: Wang, Lai, et al.
Publicado: (2018)

Early and Late Pathomechanisms in Alzheimer’s Disease: From Zinc to Amyloid-β Neurotoxicity
por: Szutowicz, Andrzej, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_9ghliiau0fiqo1tob97brphg3s