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Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification
Accumulating evidence suggests that renal cell tumors represent a group of histologically and molecularly heterogeneous diseases, even within the same histological subtype. In accordance with the increased understanding of the morphological, immunohistochemical, molecular, and epidemiological charac...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666876/ https://www.ncbi.nlm.nih.gov/pubmed/29053609 http://dx.doi.org/10.3390/ijms18102195 |
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author | Inamura, Kentaro |
author_facet | Inamura, Kentaro |
author_sort | Inamura, Kentaro |
collection | PubMed |
description | Accumulating evidence suggests that renal cell tumors represent a group of histologically and molecularly heterogeneous diseases, even within the same histological subtype. In accordance with the increased understanding of the morphological, immunohistochemical, molecular, and epidemiological characteristics of renal cell tumors, the World Health Organization (WHO) classification of renal cell tumors has been modified. This review provides perspectives on both new and current subtypes of renal cell tumors, as well as on the emerging/provisional renal cell carcinomas in the new 2016 WHO classification, which focuses on features of their molecular pathological epidemiology. The WHO classification will require additional revisions to enable the classification of renal cell tumors as clinically meaningful subtypes and provide a better understanding of the unique characteristics of renal cell tumors. |
format | Online Article Text |
id | pubmed-5666876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56668762017-11-09 Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification Inamura, Kentaro Int J Mol Sci Review Accumulating evidence suggests that renal cell tumors represent a group of histologically and molecularly heterogeneous diseases, even within the same histological subtype. In accordance with the increased understanding of the morphological, immunohistochemical, molecular, and epidemiological characteristics of renal cell tumors, the World Health Organization (WHO) classification of renal cell tumors has been modified. This review provides perspectives on both new and current subtypes of renal cell tumors, as well as on the emerging/provisional renal cell carcinomas in the new 2016 WHO classification, which focuses on features of their molecular pathological epidemiology. The WHO classification will require additional revisions to enable the classification of renal cell tumors as clinically meaningful subtypes and provide a better understanding of the unique characteristics of renal cell tumors. MDPI 2017-10-20 /pmc/articles/PMC5666876/ /pubmed/29053609 http://dx.doi.org/10.3390/ijms18102195 Text en © 2017 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Inamura, Kentaro Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification |
title | Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification |
title_full | Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification |
title_fullStr | Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification |
title_full_unstemmed | Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification |
title_short | Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification |
title_sort | renal cell tumors: understanding their molecular pathological epidemiology and the 2016 who classification |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666876/ https://www.ncbi.nlm.nih.gov/pubmed/29053609 http://dx.doi.org/10.3390/ijms18102195 |
work_keys_str_mv | AT inamurakentaro renalcelltumorsunderstandingtheirmolecularpathologicalepidemiologyandthe2016whoclassification |