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Platelets and Multi-Organ Failure in Sepsis

Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets...

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Detalles Bibliográficos
Autores principales: Greco, Elisabetta, Lupia, Enrico, Bosco, Ornella, Vizio, Barbara, Montrucchio, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666881/
https://www.ncbi.nlm.nih.gov/pubmed/29053592
http://dx.doi.org/10.3390/ijms18102200
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author Greco, Elisabetta
Lupia, Enrico
Bosco, Ornella
Vizio, Barbara
Montrucchio, Giuseppe
author_facet Greco, Elisabetta
Lupia, Enrico
Bosco, Ornella
Vizio, Barbara
Montrucchio, Giuseppe
author_sort Greco, Elisabetta
collection PubMed
description Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets in the pathogenesis of multi-organ failure. Septic shock is characterised by a dysregulated inflammatory response, which can impair the microcirculation and lead to organ injury. Being at the crossroads between the immune system, clotting cascade, and endothelial cells, platelets seem to be an appealing central mediator and possible therapeutic target in sepsis. This review focuses on the pathogenic role of platelets in septic organ dysfunction in humans and animal models.
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spelling pubmed-56668812017-11-09 Platelets and Multi-Organ Failure in Sepsis Greco, Elisabetta Lupia, Enrico Bosco, Ornella Vizio, Barbara Montrucchio, Giuseppe Int J Mol Sci Review Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets in the pathogenesis of multi-organ failure. Septic shock is characterised by a dysregulated inflammatory response, which can impair the microcirculation and lead to organ injury. Being at the crossroads between the immune system, clotting cascade, and endothelial cells, platelets seem to be an appealing central mediator and possible therapeutic target in sepsis. This review focuses on the pathogenic role of platelets in septic organ dysfunction in humans and animal models. MDPI 2017-10-20 /pmc/articles/PMC5666881/ /pubmed/29053592 http://dx.doi.org/10.3390/ijms18102200 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Greco, Elisabetta
Lupia, Enrico
Bosco, Ornella
Vizio, Barbara
Montrucchio, Giuseppe
Platelets and Multi-Organ Failure in Sepsis
title Platelets and Multi-Organ Failure in Sepsis
title_full Platelets and Multi-Organ Failure in Sepsis
title_fullStr Platelets and Multi-Organ Failure in Sepsis
title_full_unstemmed Platelets and Multi-Organ Failure in Sepsis
title_short Platelets and Multi-Organ Failure in Sepsis
title_sort platelets and multi-organ failure in sepsis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666881/
https://www.ncbi.nlm.nih.gov/pubmed/29053592
http://dx.doi.org/10.3390/ijms18102200
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