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Platelets and Multi-Organ Failure in Sepsis
Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666881/ https://www.ncbi.nlm.nih.gov/pubmed/29053592 http://dx.doi.org/10.3390/ijms18102200 |
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author | Greco, Elisabetta Lupia, Enrico Bosco, Ornella Vizio, Barbara Montrucchio, Giuseppe |
author_facet | Greco, Elisabetta Lupia, Enrico Bosco, Ornella Vizio, Barbara Montrucchio, Giuseppe |
author_sort | Greco, Elisabetta |
collection | PubMed |
description | Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets in the pathogenesis of multi-organ failure. Septic shock is characterised by a dysregulated inflammatory response, which can impair the microcirculation and lead to organ injury. Being at the crossroads between the immune system, clotting cascade, and endothelial cells, platelets seem to be an appealing central mediator and possible therapeutic target in sepsis. This review focuses on the pathogenic role of platelets in septic organ dysfunction in humans and animal models. |
format | Online Article Text |
id | pubmed-5666881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56668812017-11-09 Platelets and Multi-Organ Failure in Sepsis Greco, Elisabetta Lupia, Enrico Bosco, Ornella Vizio, Barbara Montrucchio, Giuseppe Int J Mol Sci Review Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets in the pathogenesis of multi-organ failure. Septic shock is characterised by a dysregulated inflammatory response, which can impair the microcirculation and lead to organ injury. Being at the crossroads between the immune system, clotting cascade, and endothelial cells, platelets seem to be an appealing central mediator and possible therapeutic target in sepsis. This review focuses on the pathogenic role of platelets in septic organ dysfunction in humans and animal models. MDPI 2017-10-20 /pmc/articles/PMC5666881/ /pubmed/29053592 http://dx.doi.org/10.3390/ijms18102200 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Greco, Elisabetta Lupia, Enrico Bosco, Ornella Vizio, Barbara Montrucchio, Giuseppe Platelets and Multi-Organ Failure in Sepsis |
title | Platelets and Multi-Organ Failure in Sepsis |
title_full | Platelets and Multi-Organ Failure in Sepsis |
title_fullStr | Platelets and Multi-Organ Failure in Sepsis |
title_full_unstemmed | Platelets and Multi-Organ Failure in Sepsis |
title_short | Platelets and Multi-Organ Failure in Sepsis |
title_sort | platelets and multi-organ failure in sepsis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666881/ https://www.ncbi.nlm.nih.gov/pubmed/29053592 http://dx.doi.org/10.3390/ijms18102200 |
work_keys_str_mv | AT grecoelisabetta plateletsandmultiorganfailureinsepsis AT lupiaenrico plateletsandmultiorganfailureinsepsis AT boscoornella plateletsandmultiorganfailureinsepsis AT viziobarbara plateletsandmultiorganfailureinsepsis AT montrucchiogiuseppe plateletsandmultiorganfailureinsepsis |