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Calcium‐overloaded sympathetic preganglionic neurons in a case of severe sepsis with anorexia nervosa

AIM: We aimed to show the status of intracellular elements in sympathetic preganglionic neurons in an autopsy case of a 55‐year‐old woman with severe sepsis and cardiac dysfunction with anorexia nervosa. METHODS: Our methods include a case report and pathological examinations of autopsied tissues us...

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Detalles Bibliográficos
Autores principales: Kinebuchi, Miyuki, Matsuura, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667258/
https://www.ncbi.nlm.nih.gov/pubmed/29123716
http://dx.doi.org/10.1002/ams2.100
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author Kinebuchi, Miyuki
Matsuura, Akihiro
author_facet Kinebuchi, Miyuki
Matsuura, Akihiro
author_sort Kinebuchi, Miyuki
collection PubMed
description AIM: We aimed to show the status of intracellular elements in sympathetic preganglionic neurons in an autopsy case of a 55‐year‐old woman with severe sepsis and cardiac dysfunction with anorexia nervosa. METHODS: Our methods include a case report and pathological examinations of autopsied tissues using synchrotron‐generated microbeam X‐ray fluorescence analysis. RESULTS: A case report of severe sepsis and myocardial dysfunction. The patient had sudden short cardiac arrest without arrhythmia and sequelae, and echocardiogram showed negative inotropic change. The X‐ray fluorescence analysis of autopsied tissues indicated an unusually high concentration of cytosolic calcium in sympathetic preganglionic neurons. However, there were no significant pathological findings of damage in the heart or the cardiovascular autonomic nuclei in the central nervous system. CONCLUSION: The data indicate that dysfunction of the sympathetic preganglionic neurons exists in a patient of severe sepsis and cardiac dysfunction with anorexia nervosa.
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spelling pubmed-56672582017-11-09 Calcium‐overloaded sympathetic preganglionic neurons in a case of severe sepsis with anorexia nervosa Kinebuchi, Miyuki Matsuura, Akihiro Acute Med Surg Original Articles AIM: We aimed to show the status of intracellular elements in sympathetic preganglionic neurons in an autopsy case of a 55‐year‐old woman with severe sepsis and cardiac dysfunction with anorexia nervosa. METHODS: Our methods include a case report and pathological examinations of autopsied tissues using synchrotron‐generated microbeam X‐ray fluorescence analysis. RESULTS: A case report of severe sepsis and myocardial dysfunction. The patient had sudden short cardiac arrest without arrhythmia and sequelae, and echocardiogram showed negative inotropic change. The X‐ray fluorescence analysis of autopsied tissues indicated an unusually high concentration of cytosolic calcium in sympathetic preganglionic neurons. However, there were no significant pathological findings of damage in the heart or the cardiovascular autonomic nuclei in the central nervous system. CONCLUSION: The data indicate that dysfunction of the sympathetic preganglionic neurons exists in a patient of severe sepsis and cardiac dysfunction with anorexia nervosa. John Wiley and Sons Inc. 2014-12-15 /pmc/articles/PMC5667258/ /pubmed/29123716 http://dx.doi.org/10.1002/ams2.100 Text en © 2014 The Authors. Acute Medicine & Surgery published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Association for Acute Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Kinebuchi, Miyuki
Matsuura, Akihiro
Calcium‐overloaded sympathetic preganglionic neurons in a case of severe sepsis with anorexia nervosa
title Calcium‐overloaded sympathetic preganglionic neurons in a case of severe sepsis with anorexia nervosa
title_full Calcium‐overloaded sympathetic preganglionic neurons in a case of severe sepsis with anorexia nervosa
title_fullStr Calcium‐overloaded sympathetic preganglionic neurons in a case of severe sepsis with anorexia nervosa
title_full_unstemmed Calcium‐overloaded sympathetic preganglionic neurons in a case of severe sepsis with anorexia nervosa
title_short Calcium‐overloaded sympathetic preganglionic neurons in a case of severe sepsis with anorexia nervosa
title_sort calcium‐overloaded sympathetic preganglionic neurons in a case of severe sepsis with anorexia nervosa
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667258/
https://www.ncbi.nlm.nih.gov/pubmed/29123716
http://dx.doi.org/10.1002/ams2.100
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