Preclinical activity of DCZ3301, a novel aryl-guanidino compound in the therapy of multiple myeloma

We synthesized a novel aryl-guanidino compound, DCZ3301, and found that it has potent cytotoxicity against multiple human cancer cell lines. The anticancer activity was most potent against multiple myeloma (MM). DCZ3301 induced cytotoxicity in MM cell lines, as well as patient myeloma cells, in part...

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Detalles Bibliográficos
Autores principales: Gao, Minjie, Li, Bo, Sun, Xi, Zhou, Yunfei, Wang, Yingcong, Tompkins, Van S., Xu, Zhijian, Indima, Nekitsing, Wang, Houcai, Xiao, Wenqin, Gao, Lu, Chen, Gege, Wu, Huiqun, Wu, Xiaosong, Kong, Yuanyuan, Xie, Bingqian, Zhang, Yiwen, Chang, Gaomei, Hu, Liangning, Yang, Guang, Dai, Bojie, Tao, Yi, Zhu, Weiliang, Shi, Jumei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667341/
https://www.ncbi.nlm.nih.gov/pubmed/29109769
http://dx.doi.org/10.7150/thno.18345

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