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Phosphodiesterase Inhibitors Sildenafil and Vardenafil Reduce Zebrafish Rod Photoreceptor Outer Segment Shedding

PURPOSE: The vertebrate rod photoreceptor undergoes daily growth and shedding to renew the rod outer segment (ROS), a modified cilium that contains the phototransduction machinery. It has been demonstrated that ROS shedding is regulated by the light–dark cycle; however, we do not yet have a satisfac...

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Detalles Bibliográficos
Autores principales:	Campbell, Leah J., Jensen, Abbie M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2017
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667398/ https://www.ncbi.nlm.nih.gov/pubmed/29094165 http://dx.doi.org/10.1167/iovs.17-21958

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