A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair

As central nodes in cardiomyocyte signaling, nuclear AKT appears to play a cardio-protective role in cardiovascular disease. Here we describe a circular RNA, circ-Amotl1 that is highly expressed in neonatal human cardiac tissue, and potentiates AKT-enhanced cardiomyocyte survival. We hypothesize tha...

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Detalles Bibliográficos
Autores principales: Zeng, Yan, Du, William W., Wu, Yingya, Yang, Zhenguo, Awan, Faryal Mehwish, Li, Xiangmin, Yang, Weining, Zhang, Chao, Yang, Qi, Yee, Albert, Chen, Yu, Yang, Fenghua, Sun, Huan, Huang, Ren, Yee, Albert J, Li, Ren-Ke, Wu, Zhongkai, Backx, Peter H, Yang, Burton B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667408/
https://www.ncbi.nlm.nih.gov/pubmed/29109781
http://dx.doi.org/10.7150/thno.19764

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