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A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction
Myocardial infarction (MI) results in dysfunction and irreversible loss of cardiomyocytes and is among the most serious health threats today. Bone marrow mesenchymal stem cells (BMSCs), with their capacity for multidirectional differentiation, low immunogenicity, and high portability, can serve as i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667518/ https://www.ncbi.nlm.nih.gov/pubmed/29096705 http://dx.doi.org/10.1186/s13287-017-0697-9 |
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author | Miao, Chi Lei, Mingming Hu, Weina Han, Shuo Wang, Qi |
author_facet | Miao, Chi Lei, Mingming Hu, Weina Han, Shuo Wang, Qi |
author_sort | Miao, Chi |
collection | PubMed |
description | Myocardial infarction (MI) results in dysfunction and irreversible loss of cardiomyocytes and is among the most serious health threats today. Bone marrow mesenchymal stem cells (BMSCs), with their capacity for multidirectional differentiation, low immunogenicity, and high portability, can serve as ideal seed cells in cardiovascular disease therapy. In this review, we examine recent literature concerning the application of BMSCs for the treatment of MI and consider the following aspects: activity of transplanted cells, migration and homing of BMSCs, immunomodulatory and anti-inflammatory effects of BMSCs, anti-fibrotic activity of BMSCs, the role of BMSCs in angiogenesis, and differentiation of BMSCs into cardiomyocyte-like cells and endothelial cells. Each aspect is complementary to the others and together they promote the repair of cardiomyocytes by BMSCs after MI. Although transplantation of BMSCs has enabled new options for MI treatment, the critical issue we must now address is the reduced viability of transplanted BMSCs due to inadequate blood supply, poor nourishment of cells, and generation of free radicals. More clinical trials are needed to prove the therapeutic potential of BMSCs in MI. |
format | Online Article Text |
id | pubmed-5667518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-56675182017-11-08 A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction Miao, Chi Lei, Mingming Hu, Weina Han, Shuo Wang, Qi Stem Cell Res Ther Review Myocardial infarction (MI) results in dysfunction and irreversible loss of cardiomyocytes and is among the most serious health threats today. Bone marrow mesenchymal stem cells (BMSCs), with their capacity for multidirectional differentiation, low immunogenicity, and high portability, can serve as ideal seed cells in cardiovascular disease therapy. In this review, we examine recent literature concerning the application of BMSCs for the treatment of MI and consider the following aspects: activity of transplanted cells, migration and homing of BMSCs, immunomodulatory and anti-inflammatory effects of BMSCs, anti-fibrotic activity of BMSCs, the role of BMSCs in angiogenesis, and differentiation of BMSCs into cardiomyocyte-like cells and endothelial cells. Each aspect is complementary to the others and together they promote the repair of cardiomyocytes by BMSCs after MI. Although transplantation of BMSCs has enabled new options for MI treatment, the critical issue we must now address is the reduced viability of transplanted BMSCs due to inadequate blood supply, poor nourishment of cells, and generation of free radicals. More clinical trials are needed to prove the therapeutic potential of BMSCs in MI. BioMed Central 2017-11-02 /pmc/articles/PMC5667518/ /pubmed/29096705 http://dx.doi.org/10.1186/s13287-017-0697-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Miao, Chi Lei, Mingming Hu, Weina Han, Shuo Wang, Qi A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction |
title | A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction |
title_full | A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction |
title_fullStr | A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction |
title_full_unstemmed | A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction |
title_short | A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction |
title_sort | brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667518/ https://www.ncbi.nlm.nih.gov/pubmed/29096705 http://dx.doi.org/10.1186/s13287-017-0697-9 |
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