Access to enantioenriched 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter by Pd-catalyzed asymmetric intermolecular Heck reaction

A palladium-catalyzed intermolecular asymmetric Heck reaction with dihydrofurans with a trisubstituted double bond is reported. The use of two different chiral ligands provides access to valuable 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter with high levels of regio- and enant...

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Autores principales: Borrajo-Calleja, Gustavo M., Bizet, Vincent, Bürgi, Thomas, Mazet, Clément
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667573/
https://www.ncbi.nlm.nih.gov/pubmed/29142715
http://dx.doi.org/10.1039/c5sc01460c
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author Borrajo-Calleja, Gustavo M.
Bizet, Vincent
Bürgi, Thomas
Mazet, Clément
author_facet Borrajo-Calleja, Gustavo M.
Bizet, Vincent
Bürgi, Thomas
Mazet, Clément
author_sort Borrajo-Calleja, Gustavo M.
collection PubMed
description A palladium-catalyzed intermolecular asymmetric Heck reaction with dihydrofurans with a trisubstituted double bond is reported. The use of two different chiral ligands provides access to valuable 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter with high levels of regio- and enantiocontrol.
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spelling pubmed-56675732017-11-15 Access to enantioenriched 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter by Pd-catalyzed asymmetric intermolecular Heck reaction Borrajo-Calleja, Gustavo M. Bizet, Vincent Bürgi, Thomas Mazet, Clément Chem Sci Chemistry A palladium-catalyzed intermolecular asymmetric Heck reaction with dihydrofurans with a trisubstituted double bond is reported. The use of two different chiral ligands provides access to valuable 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter with high levels of regio- and enantiocontrol. Royal Society of Chemistry 2015-08-01 2015-06-03 /pmc/articles/PMC5667573/ /pubmed/29142715 http://dx.doi.org/10.1039/c5sc01460c Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Borrajo-Calleja, Gustavo M.
Bizet, Vincent
Bürgi, Thomas
Mazet, Clément
Access to enantioenriched 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter by Pd-catalyzed asymmetric intermolecular Heck reaction
title Access to enantioenriched 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter by Pd-catalyzed asymmetric intermolecular Heck reaction
title_full Access to enantioenriched 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter by Pd-catalyzed asymmetric intermolecular Heck reaction
title_fullStr Access to enantioenriched 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter by Pd-catalyzed asymmetric intermolecular Heck reaction
title_full_unstemmed Access to enantioenriched 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter by Pd-catalyzed asymmetric intermolecular Heck reaction
title_short Access to enantioenriched 2,3- and 2,5-dihydrofurans with a fully substituted C2 stereocenter by Pd-catalyzed asymmetric intermolecular Heck reaction
title_sort access to enantioenriched 2,3- and 2,5-dihydrofurans with a fully substituted c2 stereocenter by pd-catalyzed asymmetric intermolecular heck reaction
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667573/
https://www.ncbi.nlm.nih.gov/pubmed/29142715
http://dx.doi.org/10.1039/c5sc01460c
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