Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses

BACKGROUND: Newborns display distinct immune responses, leaving them vulnerable to infections and impairing immunization. Targeting newborn dendritic cells (DCs), which integrate vaccine signals into adaptive immune responses, might enable development of age-specific vaccine formulations to overcome...

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Detalles Bibliográficos
Autores principales: Dowling, David J., Scott, Evan A., Scheid, Annette, Bergelson, Ilana, Joshi, Sweta, Pietrasanta, Carlo, Brightman, Spencer, Sanchez-Schmitz, Guzman, Van Haren, Simon D., Ninković, Jana, Kats, Dina, Guiducci, Cristiana, de Titta, Alexandre, Bonner, Daniel K., Hirosue, Sachiko, Swartz, Melody A., Hubbell, Jeffrey A., Levy, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mosby 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667586/
https://www.ncbi.nlm.nih.gov/pubmed/28343701
http://dx.doi.org/10.1016/j.jaci.2016.12.985

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