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Proteomic analysis of filaggrin deficiency identifies molecular signatures characteristic of atopic eczema

BACKGROUND: Atopic eczema (AE) is characterized by skin barrier and immune dysfunction. Null mutations in filaggrin (FLG), a key epidermal barrier protein, strongly predispose to AE; however, the precise role of FLG deficiency in AE pathogenesis remains incompletely understood. OBJECTIVES: We sought...

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Detalles Bibliográficos
Autores principales:	Elias, Martina S., Long, Heather A., Newman, Carla F., Wilson, Paul A., West, Andrew, McGill, Paul J., Wu, Keith C., Donaldson, Michael J., Reynolds, Nick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mosby 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667587/ https://www.ncbi.nlm.nih.gov/pubmed/28479159 http://dx.doi.org/10.1016/j.jaci.2017.01.039

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