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Association study between ZFHX3 gene polymorphisms and obesity in Korean population

The aim of this study is to investigate whether single nucleotide polymorphisms (SNPs) of zinc finger homeobox 3 (ZFHX3 ) gene are susceptibility to obesity. Recently, several study suggested that specific polymorphisms in various genes may have effect to obesity. In present study, 54 SNPs of ZFHX3...

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Autor principal: Yang, Seung-Ae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Exercise Rehabilitation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667630/
https://www.ncbi.nlm.nih.gov/pubmed/29114518
http://dx.doi.org/10.12965/jer.1735080.540
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author Yang, Seung-Ae
author_facet Yang, Seung-Ae
author_sort Yang, Seung-Ae
collection PubMed
description The aim of this study is to investigate whether single nucleotide polymorphisms (SNPs) of zinc finger homeobox 3 (ZFHX3 ) gene are susceptibility to obesity. Recently, several study suggested that specific polymorphisms in various genes may have effect to obesity. In present study, 54 SNPs of ZFHX3 gene were genotyped in 209 overweight and obese patients with a body mass index (BMI)≥23 kg/m(2) (mean±standard deviation, 44.7±6.4 kg/m(2)) and 159 healthy controls with a BMI of 18.5–23.0 kg/m(2) (43.6±6.2 kg/m(2)). Genotyping of each SNP was performed by custom DNA chip. Logistic regression models (dominant, recessive, and log-additive models) were used to calculate odds ratio, 95% confidence interval, and P-values. Significant association was considered at P<0.05. Among tested SNPs in ZFHX3 genes, seven SNPs of ZFHX3 gene showed significant association with obesity (P<0.05 in each model, respectively). In conclusion, these results indicate that SNPs of ZFHX3 gene might be contributed to development of obesity in the Korean population.
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spelling pubmed-56676302017-11-07 Association study between ZFHX3 gene polymorphisms and obesity in Korean population Yang, Seung-Ae J Exerc Rehabil Original Article The aim of this study is to investigate whether single nucleotide polymorphisms (SNPs) of zinc finger homeobox 3 (ZFHX3 ) gene are susceptibility to obesity. Recently, several study suggested that specific polymorphisms in various genes may have effect to obesity. In present study, 54 SNPs of ZFHX3 gene were genotyped in 209 overweight and obese patients with a body mass index (BMI)≥23 kg/m(2) (mean±standard deviation, 44.7±6.4 kg/m(2)) and 159 healthy controls with a BMI of 18.5–23.0 kg/m(2) (43.6±6.2 kg/m(2)). Genotyping of each SNP was performed by custom DNA chip. Logistic regression models (dominant, recessive, and log-additive models) were used to calculate odds ratio, 95% confidence interval, and P-values. Significant association was considered at P<0.05. Among tested SNPs in ZFHX3 genes, seven SNPs of ZFHX3 gene showed significant association with obesity (P<0.05 in each model, respectively). In conclusion, these results indicate that SNPs of ZFHX3 gene might be contributed to development of obesity in the Korean population. Korean Society of Exercise Rehabilitation 2017-08-29 /pmc/articles/PMC5667630/ /pubmed/29114518 http://dx.doi.org/10.12965/jer.1735080.540 Text en Copyright © 2017 Korean Society of Exercise Rehabilitation This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yang, Seung-Ae
Association study between ZFHX3 gene polymorphisms and obesity in Korean population
title Association study between ZFHX3 gene polymorphisms and obesity in Korean population
title_full Association study between ZFHX3 gene polymorphisms and obesity in Korean population
title_fullStr Association study between ZFHX3 gene polymorphisms and obesity in Korean population
title_full_unstemmed Association study between ZFHX3 gene polymorphisms and obesity in Korean population
title_short Association study between ZFHX3 gene polymorphisms and obesity in Korean population
title_sort association study between zfhx3 gene polymorphisms and obesity in korean population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667630/
https://www.ncbi.nlm.nih.gov/pubmed/29114518
http://dx.doi.org/10.12965/jer.1735080.540
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