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Brain gray matter structural network in myotonic dystrophy type 1
This study aimed to investigate abnormalities in structural covariance network constructed from gray matter volume in myotonic dystrophy type 1 (DM1) patients by using graph theoretical analysis for further clarification of the underlying mechanisms of central nervous system involvement. Twenty-eigh...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667809/ https://www.ncbi.nlm.nih.gov/pubmed/29095898 http://dx.doi.org/10.1371/journal.pone.0187343 |
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author | Sugiyama, Atsuhiko Sone, Daichi Sato, Noriko Kimura, Yukio Ota, Miho Maikusa, Norihide Maekawa, Tomoko Enokizono, Mikako Mori-Yoshimura, Madoka Ohya, Yasushi Kuwabara, Satoshi Matsuda, Hiroshi |
author_facet | Sugiyama, Atsuhiko Sone, Daichi Sato, Noriko Kimura, Yukio Ota, Miho Maikusa, Norihide Maekawa, Tomoko Enokizono, Mikako Mori-Yoshimura, Madoka Ohya, Yasushi Kuwabara, Satoshi Matsuda, Hiroshi |
author_sort | Sugiyama, Atsuhiko |
collection | PubMed |
description | This study aimed to investigate abnormalities in structural covariance network constructed from gray matter volume in myotonic dystrophy type 1 (DM1) patients by using graph theoretical analysis for further clarification of the underlying mechanisms of central nervous system involvement. Twenty-eight DM1 patients (4 childhood onset, 10 juvenile onset, 14 adult onset), excluding three cases from 31 consecutive patients who underwent magnetic resonance imaging in a certain period, and 28 age- and sex- matched healthy control subjects were included in this study. The normalized gray matter images of both groups were subjected to voxel based morphometry (VBM) and Graph Analysis Toolbox for graph theoretical analysis. VBM revealed extensive gray matter atrophy in DM1 patients, including cortical and subcortical structures. On graph theoretical analysis, there were no significant differences between DM1 and control groups in terms of the global measures of connectivity. Betweenness centrality was increased in several regions including the left fusiform gyrus, whereas it was decreased in the right striatum. The absence of significant differences between the groups in global network measurements on graph theoretical analysis is consistent with the fact that the general cognitive function is preserved in DM1 patients. In DM1 patients, increased connectivity in the left fusiform gyrus and decreased connectivity in the right striatum might be associated with impairment in face perception and theory of mind, and schizotypal-paranoid personality traits, respectively. |
format | Online Article Text |
id | pubmed-5667809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-56678092017-11-17 Brain gray matter structural network in myotonic dystrophy type 1 Sugiyama, Atsuhiko Sone, Daichi Sato, Noriko Kimura, Yukio Ota, Miho Maikusa, Norihide Maekawa, Tomoko Enokizono, Mikako Mori-Yoshimura, Madoka Ohya, Yasushi Kuwabara, Satoshi Matsuda, Hiroshi PLoS One Research Article This study aimed to investigate abnormalities in structural covariance network constructed from gray matter volume in myotonic dystrophy type 1 (DM1) patients by using graph theoretical analysis for further clarification of the underlying mechanisms of central nervous system involvement. Twenty-eight DM1 patients (4 childhood onset, 10 juvenile onset, 14 adult onset), excluding three cases from 31 consecutive patients who underwent magnetic resonance imaging in a certain period, and 28 age- and sex- matched healthy control subjects were included in this study. The normalized gray matter images of both groups were subjected to voxel based morphometry (VBM) and Graph Analysis Toolbox for graph theoretical analysis. VBM revealed extensive gray matter atrophy in DM1 patients, including cortical and subcortical structures. On graph theoretical analysis, there were no significant differences between DM1 and control groups in terms of the global measures of connectivity. Betweenness centrality was increased in several regions including the left fusiform gyrus, whereas it was decreased in the right striatum. The absence of significant differences between the groups in global network measurements on graph theoretical analysis is consistent with the fact that the general cognitive function is preserved in DM1 patients. In DM1 patients, increased connectivity in the left fusiform gyrus and decreased connectivity in the right striatum might be associated with impairment in face perception and theory of mind, and schizotypal-paranoid personality traits, respectively. Public Library of Science 2017-11-02 /pmc/articles/PMC5667809/ /pubmed/29095898 http://dx.doi.org/10.1371/journal.pone.0187343 Text en © 2017 Sugiyama et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sugiyama, Atsuhiko Sone, Daichi Sato, Noriko Kimura, Yukio Ota, Miho Maikusa, Norihide Maekawa, Tomoko Enokizono, Mikako Mori-Yoshimura, Madoka Ohya, Yasushi Kuwabara, Satoshi Matsuda, Hiroshi Brain gray matter structural network in myotonic dystrophy type 1 |
title | Brain gray matter structural network in myotonic dystrophy type 1 |
title_full | Brain gray matter structural network in myotonic dystrophy type 1 |
title_fullStr | Brain gray matter structural network in myotonic dystrophy type 1 |
title_full_unstemmed | Brain gray matter structural network in myotonic dystrophy type 1 |
title_short | Brain gray matter structural network in myotonic dystrophy type 1 |
title_sort | brain gray matter structural network in myotonic dystrophy type 1 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667809/ https://www.ncbi.nlm.nih.gov/pubmed/29095898 http://dx.doi.org/10.1371/journal.pone.0187343 |
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