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Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p

Growing evidences indicated that Long noncoding RNAs (lncRNAs) played important roles in tumor initiation and progression. However, the function and mechnism of lncRNA ferritin heavy chain 1 pseudogene 3 (FTH1P3) remain unknown in uveal melanoma. We showed that the expression level of FTH1P3 was upr...

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Autores principales: Zheng, Xiaoli, Tang, Hongwei, Zhao, Xiaofeng, Sun, Yamei, Jiang, Yanfang, Liu, Yonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667836/
https://www.ncbi.nlm.nih.gov/pubmed/29095823
http://dx.doi.org/10.1371/journal.pone.0184746
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author Zheng, Xiaoli
Tang, Hongwei
Zhao, Xiaofeng
Sun, Yamei
Jiang, Yanfang
Liu, Yonghua
author_facet Zheng, Xiaoli
Tang, Hongwei
Zhao, Xiaofeng
Sun, Yamei
Jiang, Yanfang
Liu, Yonghua
author_sort Zheng, Xiaoli
collection PubMed
description Growing evidences indicated that Long noncoding RNAs (lncRNAs) played important roles in tumor initiation and progression. However, the function and mechnism of lncRNA ferritin heavy chain 1 pseudogene 3 (FTH1P3) remain unknown in uveal melanoma. We showed that the expression level of FTH1P3 was upregulated in uveal melanoma cell lines and tissues. Elevated expression of FTH1P3 promoted uveal melanoma cell proliferation, cell cycle and migration. Moreover, we found that FTH1P3 was a direct target gene of miR-224-5p in uveal melanoma cell. Overexpression of FTH1P3 suppressed miR-224-5p expression and promoted the expression of Rac1 and Fizzled 5, which were the direct target genes of miR-224-5p. Furthermore, we showed that miR-224-5p expression level was downregulated in uveal melanoma cell lines and tissues. FTH1P3 expression was inversely correlated with the miR-224-5p expression in uveal melanoma tissues. Ectopic expression of miR-224-5p decreased uveal melanoma cell proliferation, cell cycle and migration. Elevated expression of FTH1P3 enhanced uveal melanoma cell proliferation and migration by inhibiting miR-224-5p expression. These results suggest that lncRNA FTH1P3 plays a crucial role in uveal melanoma. Investigation of the underlying mechanism may be a target for the treatment of uveal melanoma.
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spelling pubmed-56678362017-11-17 Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p Zheng, Xiaoli Tang, Hongwei Zhao, Xiaofeng Sun, Yamei Jiang, Yanfang Liu, Yonghua PLoS One Research Article Growing evidences indicated that Long noncoding RNAs (lncRNAs) played important roles in tumor initiation and progression. However, the function and mechnism of lncRNA ferritin heavy chain 1 pseudogene 3 (FTH1P3) remain unknown in uveal melanoma. We showed that the expression level of FTH1P3 was upregulated in uveal melanoma cell lines and tissues. Elevated expression of FTH1P3 promoted uveal melanoma cell proliferation, cell cycle and migration. Moreover, we found that FTH1P3 was a direct target gene of miR-224-5p in uveal melanoma cell. Overexpression of FTH1P3 suppressed miR-224-5p expression and promoted the expression of Rac1 and Fizzled 5, which were the direct target genes of miR-224-5p. Furthermore, we showed that miR-224-5p expression level was downregulated in uveal melanoma cell lines and tissues. FTH1P3 expression was inversely correlated with the miR-224-5p expression in uveal melanoma tissues. Ectopic expression of miR-224-5p decreased uveal melanoma cell proliferation, cell cycle and migration. Elevated expression of FTH1P3 enhanced uveal melanoma cell proliferation and migration by inhibiting miR-224-5p expression. These results suggest that lncRNA FTH1P3 plays a crucial role in uveal melanoma. Investigation of the underlying mechanism may be a target for the treatment of uveal melanoma. Public Library of Science 2017-11-02 /pmc/articles/PMC5667836/ /pubmed/29095823 http://dx.doi.org/10.1371/journal.pone.0184746 Text en © 2017 Zheng et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zheng, Xiaoli
Tang, Hongwei
Zhao, Xiaofeng
Sun, Yamei
Jiang, Yanfang
Liu, Yonghua
Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p
title Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p
title_full Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p
title_fullStr Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p
title_full_unstemmed Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p
title_short Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p
title_sort long non-coding rna fth1p3 facilitates uveal melanoma cell growth and invasion through mir-224-5p
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667836/
https://www.ncbi.nlm.nih.gov/pubmed/29095823
http://dx.doi.org/10.1371/journal.pone.0184746
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