Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity

Use of some HIV-1 nucleoside reverse transcriptase inhibitors (NRTI) is associated with severe adverse events. However, the exact mechanisms behind their toxicity has not been fully understood. Mitochondrial dysfunction after chronic exposure to specific NRTIs has predominantly been assigned to mito...

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Detalles Bibliográficos
Autores principales: Smith, Reuben L., Tan, Josephine M. E., Jonker, Martijs J., Jongejan, Aldo, Buissink, Thomas, Veldhuijzen, Steve, van Kampen, Antoine H. C., Brul, Stanley, van der Spek, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667870/
https://www.ncbi.nlm.nih.gov/pubmed/29095935
http://dx.doi.org/10.1371/journal.pone.0187424

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