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Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission

BACKGROUND: Proteinuria is a powerful prognostic factor for end-stage renal disease in IgA nephropathy (IgAN) patients. However, it is not known whether proteinuria exacerbations are related to seasonal changes. METHODS: We retrospectively enrolled consecutive patients diagnosed with IgAN by kidney...

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Autores principales: Inagaki, Koji, Yasuda, Yoshinari, Ando, Masahiko, Kaihan, Ahmad Baseer, Hachiya, Asaka, Ozeki, Takaya, Hishida, Manabu, Imaizumi, Takahiro, Katsuno, Takayuki, Kato, Sawako, Tsuboi, Naotake, Maruyama, Shoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667876/
https://www.ncbi.nlm.nih.gov/pubmed/29095887
http://dx.doi.org/10.1371/journal.pone.0187607
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author Inagaki, Koji
Yasuda, Yoshinari
Ando, Masahiko
Kaihan, Ahmad Baseer
Hachiya, Asaka
Ozeki, Takaya
Hishida, Manabu
Imaizumi, Takahiro
Katsuno, Takayuki
Kato, Sawako
Tsuboi, Naotake
Maruyama, Shoichi
author_facet Inagaki, Koji
Yasuda, Yoshinari
Ando, Masahiko
Kaihan, Ahmad Baseer
Hachiya, Asaka
Ozeki, Takaya
Hishida, Manabu
Imaizumi, Takahiro
Katsuno, Takayuki
Kato, Sawako
Tsuboi, Naotake
Maruyama, Shoichi
author_sort Inagaki, Koji
collection PubMed
description BACKGROUND: Proteinuria is a powerful prognostic factor for end-stage renal disease in IgA nephropathy (IgAN) patients. However, it is not known whether proteinuria exacerbations are related to seasonal changes. METHODS: We retrospectively enrolled consecutive patients diagnosed with IgAN by kidney biopsy at our hospital between 2002 and 2014. Proteinuria remission was defined as urinary protein <0.3 g/gCr in two consecutive outpatient urinalyses and exacerbation as urinary protein ≥0.75 g/gCr. Four seasons were defined: spring (March–May), summer (June–August), autumn (September–November), and winter (December–February). We performed a multivariate analysis to identify factors associated with the second remission following a proteinuria exacerbation. RESULTS: We analyzed 116 patients. Proteinuria remission and exacerbation occurred in 77, and 43 patients, respectively. The incidence of proteinuria exacerbation was significantly higher in autumn and winter than in spring and summer (p = 0.040). The cumulative second remission rate was significantly higher in patients with autumn and winter proteinuria exacerbation than in patients with spring and summer exacerbations (p = 0.0091). In multivariate analyses, exacerbation onset in autumn and winter (hazard ratio [HR], 3.51; 95% confidence interval [CI], 1.41–8.74) and intensive therapy (HR, 2.26; 95% CI, 1.05–4.88) were significantly associated with a second proteinuria remission. CONCLUSION: In IgAN patients in proteinuria remission, proteinuria exacerbation frequently occurred in autumn and winter. Exacerbations occurring in autumn and winter tended to remit early.
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spelling pubmed-56678762017-11-17 Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission Inagaki, Koji Yasuda, Yoshinari Ando, Masahiko Kaihan, Ahmad Baseer Hachiya, Asaka Ozeki, Takaya Hishida, Manabu Imaizumi, Takahiro Katsuno, Takayuki Kato, Sawako Tsuboi, Naotake Maruyama, Shoichi PLoS One Research Article BACKGROUND: Proteinuria is a powerful prognostic factor for end-stage renal disease in IgA nephropathy (IgAN) patients. However, it is not known whether proteinuria exacerbations are related to seasonal changes. METHODS: We retrospectively enrolled consecutive patients diagnosed with IgAN by kidney biopsy at our hospital between 2002 and 2014. Proteinuria remission was defined as urinary protein <0.3 g/gCr in two consecutive outpatient urinalyses and exacerbation as urinary protein ≥0.75 g/gCr. Four seasons were defined: spring (March–May), summer (June–August), autumn (September–November), and winter (December–February). We performed a multivariate analysis to identify factors associated with the second remission following a proteinuria exacerbation. RESULTS: We analyzed 116 patients. Proteinuria remission and exacerbation occurred in 77, and 43 patients, respectively. The incidence of proteinuria exacerbation was significantly higher in autumn and winter than in spring and summer (p = 0.040). The cumulative second remission rate was significantly higher in patients with autumn and winter proteinuria exacerbation than in patients with spring and summer exacerbations (p = 0.0091). In multivariate analyses, exacerbation onset in autumn and winter (hazard ratio [HR], 3.51; 95% confidence interval [CI], 1.41–8.74) and intensive therapy (HR, 2.26; 95% CI, 1.05–4.88) were significantly associated with a second proteinuria remission. CONCLUSION: In IgAN patients in proteinuria remission, proteinuria exacerbation frequently occurred in autumn and winter. Exacerbations occurring in autumn and winter tended to remit early. Public Library of Science 2017-11-02 /pmc/articles/PMC5667876/ /pubmed/29095887 http://dx.doi.org/10.1371/journal.pone.0187607 Text en © 2017 Inagaki et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Inagaki, Koji
Yasuda, Yoshinari
Ando, Masahiko
Kaihan, Ahmad Baseer
Hachiya, Asaka
Ozeki, Takaya
Hishida, Manabu
Imaizumi, Takahiro
Katsuno, Takayuki
Kato, Sawako
Tsuboi, Naotake
Maruyama, Shoichi
Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission
title Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission
title_full Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission
title_fullStr Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission
title_full_unstemmed Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission
title_short Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission
title_sort seasonal proteinuria changes in iga nephropathy patients after proteinuria remission
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667876/
https://www.ncbi.nlm.nih.gov/pubmed/29095887
http://dx.doi.org/10.1371/journal.pone.0187607
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