TRPM5 mediates acidic extracellular pH signaling and TRPM5 inhibition reduces spontaneous metastasis in mouse B16-BL6 melanoma cells

Extracellular acidity is a hallmark of solid tumors and is associated with metastasis in the tumor microenvironment. Acidic extracellular pH (pH(e)) has been found to increase intracellular Ca(2+) and matrix metalloproteinase-9 (MMP-9) expression by activating NF-κB in the mouse B16 melanoma model....

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Detalles Bibliográficos
Autores principales: Maeda, Toyonobu, Suzuki, Atsuko, Koga, Kaori, Miyamoto, Chihiro, Maehata, Yojiro, Ozawa, Shigeyuki, Hata, Ryu-Ichiro, Nagashima, Yoji, Nabeshima, Kazuki, Miyazaki, Kaoru, Kato, Yasumasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667964/
https://www.ncbi.nlm.nih.gov/pubmed/29108231
http://dx.doi.org/10.18632/oncotarget.20826

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