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Mitoketoscins: Novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs)

Previous studies have now well-established that epithelial cancer cells can utilize ketone bodies (3-hydroxybutyrate and aceto-acetate) as mitochondrial fuels, to actively promote tumor growth and metastatic dissemination. The two critical metabolic enzymes implicated in this process are OXCT1 and A...

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Detalles Bibliográficos
Autores principales:	Ozsvari, Bela, Sotgia, Federica, Simmons, Katie, Trowbridge, Rachel, Foster, Richard, Lisanti, Michael P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667966/ https://www.ncbi.nlm.nih.gov/pubmed/29108233 http://dx.doi.org/10.18632/oncotarget.21259

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