Cargando…

STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines

Pancreatic ductal adenocarcinomas (PDACs) are highly aggressive malignancies, associated with poor clinical prognosis and limited therapeutic options. Oncogenic KRAS mutations are found in over 90% of PDACs, playing a central role in tumor progression. Global gene expression profiling of PDAC reveal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grant, Trevor J., Mehta, Anita K., Gupta, Anamika, Sharif, Ahmad A.D., Arora, Kshitij S., Deshpande, Vikram, Ting, David T., Bardeesy, Nabeel, Ganem, Neil J., Hergovich, Alexander, Singh, Anurag
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667982/ https://www.ncbi.nlm.nih.gov/pubmed/29108249 http://dx.doi.org/10.18632/oncotarget.20833

Ejemplares similares

Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation
por: Bettoun, Audrey, et al.
Publicado: (2016)

Correction: Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation
por: Bettoun, Audrey, et al.
Publicado: (2018)

The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy
por: Klimek, Christina, et al.
Publicado: (2019)

The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy
por: Joffre, Carine, et al.
Publicado: (2015)

STK38 is a PPARγ-interacting protein promoting adipogenesis
por: Qian, Kun, et al.
Publicado: (2021)

Prognostic and Immunological Role of STK38 across Cancers: Friend or Foe?
por: Liu, Yankuo, et al.
Publicado: (2022)

Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33
por: Azoitei, Ninel, et al.
Publicado: (2012)

STK3 is a therapeutic target for a subset of acute myeloid leukemias
por: Camgoz, Aylin, et al.
Publicado: (2018)

A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells
por: Weïwer, Michel, et al.
Publicado: (2012)

Oncogenic Kras-Mediated Cytokine CCL15 Regulates Pancreatic Cancer Cell Migration and Invasion through ROS
por: Messex, Justin K., et al.
Publicado: (2022)

Prevention of calpain-dependent degradation of STK38 by MEKK2-mediated phosphorylation
por: Enomoto, Atsushi, et al.
Publicado: (2019)

The Role of Mammalian STK38 in DNA Damage Response and Targeting for Radio-Sensitization
por: Fukasawa, Takemichi, et al.
Publicado: (2023)

Unraveling the Role of STK11/LKB1 in Non-small Cell Lung Cancer
por: Sumbly, Vikram, et al.
Publicado: (2022)

Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes
por: Liu, Jing, et al.
Publicado: (2017)

Identification of the kinase STK25 as an upstream activator of LATS signaling
por: Lim, Sanghee, et al.
Publicado: (2019)

Concurrent Mutations in STK11 and KEAP1 Cause Treatment Resistance in KRAS Wild-type Non-small-cell Lung Cancer
por: Sumii, Masahiko, et al.
Publicado: (2023)

Photoreceptor Cell Death, Proliferation and Formation of Hybrid Rod/S-Cone Photoreceptors in the Degenerating STK38L Mutant Retina
por: Berta, Ágnes I., et al.
Publicado: (2011)

A case of synchronous mucinous metaplasia and neoplasia of the female genital tract without an STK11 or KRAS mutation()
por: Nagahama, Kiyotaka, et al.
Publicado: (2013)

Corrigendum: Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes
por: Liu, Jing, et al.
Publicado: (2017)

STK38 promotes ATM activation by acting as a reader of histone H4 ufmylation
por: Qin, Bo, et al.
Publicado: (2020)

Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations
por: Ha, Dat P., et al.
Publicado: (2022)

Nuclear GSK-3β and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN
por: Ding, Li, et al.
Publicado: (2022)

Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma
por: Schabath, Matthew B., et al.
Publicado: (2015)

Molecular Signatures of KRAS-Mutated Lung Adenocarcinoma: Analysis of Concomitant EGFR, ALK, STK11, and PD-L1 Status
por: Hsu, Jim, et al.
Publicado: (2022)

Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation
por: Rawat, Priya, et al.
Publicado: (2023)

NLRP12 downregulates the Wnt/β-catenin pathway via interaction with STK38 to suppress colorectal cancer
por: Khan, Shahanshah, et al.
Publicado: (2023)

Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38
por: Chen, Jian, et al.
Publicado: (2021)

STK system acceptance tests
por: Grau, X F
Publicado: (1997)

A Critical Review of the Prognostic and Predictive Implications of KRAS and STK11 Mutations and Co-Mutations in Metastatic Non-Small Lung Cancer
por: Manolakos, Peter, et al.
Publicado: (2023)

Dysregulated CD38 Expression on Peripheral Blood Immune Cell Subsets in SLE
por: Burns, Marie, et al.
Publicado: (2021)

Primary Resistance to Immune Checkpoint Blockade in an STK11/TP53/KRAS-Mutant Lung Adenocarcinoma with High PD-L1 Expression
por: Kwack, Won Gun, et al.
Publicado: (2020)

Synchronous mucinous metaplasia and neoplasia of the female genital tract with both pulmonary metastases and STK11/KRAS gene mutations: a case report
por: Wang, Ru, et al.
Publicado: (2023)

Untangling the KRAS mutated lung cancer subsets and its therapeutic implications
por: Ritu, Kulshrestha, et al.
Publicado: (2021)

The ubiquitin ligase Cullin5(SOCS2) regulates NDR1/STK38 stability and NF-κB transactivation
por: Paul, Indranil, et al.
Publicado: (2017)

AIF Downregulation and Its Interaction with STK3 in Renal Cell Carcinoma
por: Xu, Shengqiang, et al.
Publicado: (2014)

STK39, overexpressed in osteosarcoma, regulates osteosarcoma cell invasion and proliferation
por: Huang, Tao, et al.
Publicado: (2017)

Mapping the STK4/Hippo signaling network in prostate cancer cell
por: Ready, Damien, et al.
Publicado: (2017)

STK11 is required for the normal program of ciliated cell differentiation in airways
por: Chu, Qiqi, et al.
Publicado: (2019)

Knockout of STK10 promotes the migration and invasion of cervical cancer cells
por: Zhang, Lu, et al.
Publicado: (2020)

Lymphocyte subsets in tumour of patients with undifferentiated nasopharyngeal carcinoma: presence of lymphocytes with the phenotype of activated T cells.
por: Herait, P., et al.
Publicado: (1987)

Cannot write session to /tmp/vufind_sessions/sess_s9shlhjra5n4g7f7me470l4ak7