Local irradiation does not enhance the effect of immunostimulatory AdCD40L gene therapy combined with low dose cyclophosphamide in melanoma patients

BACKGROUND: AdCD40L is an immunostimulatory gene therapy under evaluation for advanced melanoma, including ocular melanoma. Herein, we present the final data of a Phase I/IIa trial using AdCD40L alone or in combination with low dose cyclophosphamide +/- radiation therapy. METHODS: AdCD40L is a repli...

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Detalles Bibliográficos
Autores principales: Irenaeus, Sandra, Schiza, Aglaia, Mangsbo, Sara M., Wenthe, Jessica, Eriksson, Emma, Krause, Johan, Sundin, Anders, Ahlström, Håkan, Tötterman, Thomas H., Loskog, Angelica, Ullenhag, Gustav J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667983/
https://www.ncbi.nlm.nih.gov/pubmed/29108250
http://dx.doi.org/10.18632/oncotarget.19750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667983/
https://www.ncbi.nlm.nih.gov/pubmed/29108250
http://dx.doi.org/10.18632/oncotarget.19750

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