Sphingosine kinase 1 mediates AGEs-induced fibronectin upregulation in diabetic nephropathy

Activation of sphingosine kinase 1 (SphK1) signaling pathway mediates fibronectin (FN) upregulation in glomerular mesangial cells (GMCs) under high glucose (HG) condition. However, the roles of SphK1 in advanced glycation end products (AGEs)-induced DN have not been elucidated. Here we show that AGE...

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Detalles Bibliográficos
Autores principales: Chen, Cheng, Gong, Wenyan, Li, Changzheng, Xiong, Fengxiao, Wang, Shaogui, Huang, Junying, Wang, Yu, Chen, Zhiquan, Chen, Qiuhong, Liu, Peiqing, Lan, Tian, Huang, Heqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667989/
https://www.ncbi.nlm.nih.gov/pubmed/29108256
http://dx.doi.org/10.18632/oncotarget.20205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667989/
https://www.ncbi.nlm.nih.gov/pubmed/29108256
http://dx.doi.org/10.18632/oncotarget.20205

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