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Association study of inflammatory cytokine and chemokine expression in hand foot and mouth disease
OBJECTIVE: To determine the relationship of cytokine/chemokine expression with the clinical presentation of hand, foot and mouth disease (HFMD). RESULTS: All cytokine/chemokine levels were higher in severe HFMD patients than in mild HFMD patients or controls (P < 0.01). RANTES, MCP-1, IL-4, IL-12...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668054/ https://www.ncbi.nlm.nih.gov/pubmed/29108321 http://dx.doi.org/10.18632/oncotarget.18341 |
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author | Shang, Wenzhong Qian, Suying Fang, Lijuan Han, Yong Zheng, Cuiping |
author_facet | Shang, Wenzhong Qian, Suying Fang, Lijuan Han, Yong Zheng, Cuiping |
author_sort | Shang, Wenzhong |
collection | PubMed |
description | OBJECTIVE: To determine the relationship of cytokine/chemokine expression with the clinical presentation of hand, foot and mouth disease (HFMD). RESULTS: All cytokine/chemokine levels were higher in severe HFMD patients than in mild HFMD patients or controls (P < 0.01). RANTES, MCP-1, IL-4, IL-12 and IL-18 levels were higher in mild HFMD patients than in the controls (P < 0.05). In severe HFMD, all levels (except IL-8 and IL-4) were higher in patients with encephalitis plus pulmonary edema than in those with encephalitis alone (P < 0.05). All levels (except IL-8) were higher in EV71-positive patients than in EV71-negative patients (P < 0.05). In mild HFMD, all levels (except IL-8 and IL-4) were higher in EV71-positive patients than in EV71-negative patients (P < 0.05). In severe HFMD, only RANTES, IP-10 and IFN-γ levels were higher in EV71-positive patients than in EV71-negative patients (P < 0.05). In the EV71-negative group, all levels were higher in severe HFMD than in mild HFMD (P < 0.01). In the EV71-positive group, all levels (except IL-8) were higher in severe HFMD than in mild HFMD (P < 0.01). MATERIALS AND METHODS: This study involved 28 mild HFMD patients, 44 severe HFMD patients and 26 healthy children. Venous blood was tested for cytokines (IL-4, IL-12, IL-18, TNF-α, IFN-γ) and chemokines (IL-8, RANTES, MCP-1, IP-10). Stool samples from the patients were tested for EV71 nucleic acid using reverse transcription polymerase chain reaction. CONCLUSIONS: Cytokines/chemokines participate in HFMD pathogenesis, and could have potential value in monitoring disease progression and predicting prognosis. |
format | Online Article Text |
id | pubmed-5668054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56680542017-11-04 Association study of inflammatory cytokine and chemokine expression in hand foot and mouth disease Shang, Wenzhong Qian, Suying Fang, Lijuan Han, Yong Zheng, Cuiping Oncotarget Clinical Research Paper OBJECTIVE: To determine the relationship of cytokine/chemokine expression with the clinical presentation of hand, foot and mouth disease (HFMD). RESULTS: All cytokine/chemokine levels were higher in severe HFMD patients than in mild HFMD patients or controls (P < 0.01). RANTES, MCP-1, IL-4, IL-12 and IL-18 levels were higher in mild HFMD patients than in the controls (P < 0.05). In severe HFMD, all levels (except IL-8 and IL-4) were higher in patients with encephalitis plus pulmonary edema than in those with encephalitis alone (P < 0.05). All levels (except IL-8) were higher in EV71-positive patients than in EV71-negative patients (P < 0.05). In mild HFMD, all levels (except IL-8 and IL-4) were higher in EV71-positive patients than in EV71-negative patients (P < 0.05). In severe HFMD, only RANTES, IP-10 and IFN-γ levels were higher in EV71-positive patients than in EV71-negative patients (P < 0.05). In the EV71-negative group, all levels were higher in severe HFMD than in mild HFMD (P < 0.01). In the EV71-positive group, all levels (except IL-8) were higher in severe HFMD than in mild HFMD (P < 0.01). MATERIALS AND METHODS: This study involved 28 mild HFMD patients, 44 severe HFMD patients and 26 healthy children. Venous blood was tested for cytokines (IL-4, IL-12, IL-18, TNF-α, IFN-γ) and chemokines (IL-8, RANTES, MCP-1, IP-10). Stool samples from the patients were tested for EV71 nucleic acid using reverse transcription polymerase chain reaction. CONCLUSIONS: Cytokines/chemokines participate in HFMD pathogenesis, and could have potential value in monitoring disease progression and predicting prognosis. Impact Journals LLC 2017-06-02 /pmc/articles/PMC5668054/ /pubmed/29108321 http://dx.doi.org/10.18632/oncotarget.18341 Text en Copyright: © 2017 Shang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Clinical Research Paper Shang, Wenzhong Qian, Suying Fang, Lijuan Han, Yong Zheng, Cuiping Association study of inflammatory cytokine and chemokine expression in hand foot and mouth disease |
title | Association study of inflammatory cytokine and chemokine expression in hand foot and mouth disease |
title_full | Association study of inflammatory cytokine and chemokine expression in hand foot and mouth disease |
title_fullStr | Association study of inflammatory cytokine and chemokine expression in hand foot and mouth disease |
title_full_unstemmed | Association study of inflammatory cytokine and chemokine expression in hand foot and mouth disease |
title_short | Association study of inflammatory cytokine and chemokine expression in hand foot and mouth disease |
title_sort | association study of inflammatory cytokine and chemokine expression in hand foot and mouth disease |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668054/ https://www.ncbi.nlm.nih.gov/pubmed/29108321 http://dx.doi.org/10.18632/oncotarget.18341 |
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