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Mid-arm muscle circumference as a surrogate in predicting insulin resistance in non-obese elderly individuals

The homeostatic model assessment of insulin resistance (HOMA-IR) was used to measure the degree of insulin resistance (IR). Previous literature revealed that mid-arm muscle circumference (MAMC) is one of the anthropometric indicators for nutritional status and the relationship between MAMC and HOMA-...

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Autores principales: Chao, Yuan-Ping, Lai, Yi-Fen, Kao, Tung-Wei, Peng, Tao-Chun, Lin, Yuan-Yung, Shih, Mu-Tsun, Chen, Wei-Liang, Wu, Li-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668091/
https://www.ncbi.nlm.nih.gov/pubmed/29108358
http://dx.doi.org/10.18632/oncotarget.19340
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author Chao, Yuan-Ping
Lai, Yi-Fen
Kao, Tung-Wei
Peng, Tao-Chun
Lin, Yuan-Yung
Shih, Mu-Tsun
Chen, Wei-Liang
Wu, Li-Wei
author_facet Chao, Yuan-Ping
Lai, Yi-Fen
Kao, Tung-Wei
Peng, Tao-Chun
Lin, Yuan-Yung
Shih, Mu-Tsun
Chen, Wei-Liang
Wu, Li-Wei
author_sort Chao, Yuan-Ping
collection PubMed
description The homeostatic model assessment of insulin resistance (HOMA-IR) was used to measure the degree of insulin resistance (IR). Previous literature revealed that mid-arm muscle circumference (MAMC) is one of the anthropometric indicators for nutritional status and the relationship between MAMC and HOMA-IR remains uncertain in the obese and non-obese elderly individuals. The present study included 5,607 participants aged between 60 to 84 years old, using data from the 1999 to 2006 National Health and Nutrition Examination Survey (NHANES). To further explore the association between HOMA-IR and MAMC in the obese and non-obese elderly population using multivariate Cox regression analyses, we divided the participants into obese (BMI ≥ 30 kg/m(2)) group and non-obese (19 ≤ BMI < 30 kg/m(2)) group in this study; each group was then divided into quartiles based on their MAMC levels. A positive association was noted between the MAMC and HOMA-IR in all of the designed models initially. After adjusting for multiple covariates, a higher level of the MAMC was significantly associated with elevated HOMA-IR (P < 0.05) in the non-obesity group, which was not the case in the obesity group. Additionally, subjects in the higher quartiles of MAMC tended to have higher HOMA-IR with a significant association (P for trend = 0.003 in model 1; P for trend < 0.001 in model 2, 3, and 4). These results demonstrated that the MAMC can be an auxiliary indicator of HOMA-IR in non-obese elderly individuals and may have substantial additional value in screening for IR if well extrapolated.
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spelling pubmed-56680912017-11-04 Mid-arm muscle circumference as a surrogate in predicting insulin resistance in non-obese elderly individuals Chao, Yuan-Ping Lai, Yi-Fen Kao, Tung-Wei Peng, Tao-Chun Lin, Yuan-Yung Shih, Mu-Tsun Chen, Wei-Liang Wu, Li-Wei Oncotarget Clinical Research Paper The homeostatic model assessment of insulin resistance (HOMA-IR) was used to measure the degree of insulin resistance (IR). Previous literature revealed that mid-arm muscle circumference (MAMC) is one of the anthropometric indicators for nutritional status and the relationship between MAMC and HOMA-IR remains uncertain in the obese and non-obese elderly individuals. The present study included 5,607 participants aged between 60 to 84 years old, using data from the 1999 to 2006 National Health and Nutrition Examination Survey (NHANES). To further explore the association between HOMA-IR and MAMC in the obese and non-obese elderly population using multivariate Cox regression analyses, we divided the participants into obese (BMI ≥ 30 kg/m(2)) group and non-obese (19 ≤ BMI < 30 kg/m(2)) group in this study; each group was then divided into quartiles based on their MAMC levels. A positive association was noted between the MAMC and HOMA-IR in all of the designed models initially. After adjusting for multiple covariates, a higher level of the MAMC was significantly associated with elevated HOMA-IR (P < 0.05) in the non-obesity group, which was not the case in the obesity group. Additionally, subjects in the higher quartiles of MAMC tended to have higher HOMA-IR with a significant association (P for trend = 0.003 in model 1; P for trend < 0.001 in model 2, 3, and 4). These results demonstrated that the MAMC can be an auxiliary indicator of HOMA-IR in non-obese elderly individuals and may have substantial additional value in screening for IR if well extrapolated. Impact Journals LLC 2017-07-18 /pmc/articles/PMC5668091/ /pubmed/29108358 http://dx.doi.org/10.18632/oncotarget.19340 Text en Copyright: © 2017 Chao et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Clinical Research Paper
Chao, Yuan-Ping
Lai, Yi-Fen
Kao, Tung-Wei
Peng, Tao-Chun
Lin, Yuan-Yung
Shih, Mu-Tsun
Chen, Wei-Liang
Wu, Li-Wei
Mid-arm muscle circumference as a surrogate in predicting insulin resistance in non-obese elderly individuals
title Mid-arm muscle circumference as a surrogate in predicting insulin resistance in non-obese elderly individuals
title_full Mid-arm muscle circumference as a surrogate in predicting insulin resistance in non-obese elderly individuals
title_fullStr Mid-arm muscle circumference as a surrogate in predicting insulin resistance in non-obese elderly individuals
title_full_unstemmed Mid-arm muscle circumference as a surrogate in predicting insulin resistance in non-obese elderly individuals
title_short Mid-arm muscle circumference as a surrogate in predicting insulin resistance in non-obese elderly individuals
title_sort mid-arm muscle circumference as a surrogate in predicting insulin resistance in non-obese elderly individuals
topic Clinical Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668091/
https://www.ncbi.nlm.nih.gov/pubmed/29108358
http://dx.doi.org/10.18632/oncotarget.19340
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