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Long-term postoperative survival prediction in patients with colorectal liver metastasis
Numerous factors affect the prognosis of colorectal liver metastasis (CRLM) patients after hepatic resection. We investigated several factors related to overall survival in patients with CRLM to identify those most likely to benefit from hepatic resection, and produced a rational tumor biology score...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668107/ https://www.ncbi.nlm.nih.gov/pubmed/29108374 http://dx.doi.org/10.18632/oncotarget.20322 |
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author | Wang, Kun Liu, Wei Yan, Xiao-Luan Li, Juan Xing, Bao-Cai |
author_facet | Wang, Kun Liu, Wei Yan, Xiao-Luan Li, Juan Xing, Bao-Cai |
author_sort | Wang, Kun |
collection | PubMed |
description | Numerous factors affect the prognosis of colorectal liver metastasis (CRLM) patients after hepatic resection. We investigated several factors related to overall survival in patients with CRLM to identify those most likely to benefit from hepatic resection, and produced a rational tumor biology score system. Three hundred CRLM patients treated with preoperative chemotherapy followed by hepatic resection between 2006 and 2016 were enrolled in our study. Clinicopathologic and long-term survival data were collected and assessed. Patient 1-, 3-, and 5-year overall survival rates were 92.7%, 58.3%, and 45.8%, respectively, while 1-, 3-, and 5-year disease-free survival rates were 44.7%, 28.6%, and 24.2%, respectively. Multivariate Cox regression analysis revealed poor preoperative chemotherapy response, Fong clinical risk score > 2, and KRAS mutation to be independent prognostic indicators in CRLM patients. As part of a preoperative staging system in which one point was assigned for each factor, a total score (out of 3) was predictive of long-term survival following surgery. These factors facilitate personalized prognostic assessments in CRLM patients planning for resection. |
format | Online Article Text |
id | pubmed-5668107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56681072017-11-04 Long-term postoperative survival prediction in patients with colorectal liver metastasis Wang, Kun Liu, Wei Yan, Xiao-Luan Li, Juan Xing, Bao-Cai Oncotarget Clinical Research Paper Numerous factors affect the prognosis of colorectal liver metastasis (CRLM) patients after hepatic resection. We investigated several factors related to overall survival in patients with CRLM to identify those most likely to benefit from hepatic resection, and produced a rational tumor biology score system. Three hundred CRLM patients treated with preoperative chemotherapy followed by hepatic resection between 2006 and 2016 were enrolled in our study. Clinicopathologic and long-term survival data were collected and assessed. Patient 1-, 3-, and 5-year overall survival rates were 92.7%, 58.3%, and 45.8%, respectively, while 1-, 3-, and 5-year disease-free survival rates were 44.7%, 28.6%, and 24.2%, respectively. Multivariate Cox regression analysis revealed poor preoperative chemotherapy response, Fong clinical risk score > 2, and KRAS mutation to be independent prognostic indicators in CRLM patients. As part of a preoperative staging system in which one point was assigned for each factor, a total score (out of 3) was predictive of long-term survival following surgery. These factors facilitate personalized prognostic assessments in CRLM patients planning for resection. Impact Journals LLC 2017-08-18 /pmc/articles/PMC5668107/ /pubmed/29108374 http://dx.doi.org/10.18632/oncotarget.20322 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Clinical Research Paper Wang, Kun Liu, Wei Yan, Xiao-Luan Li, Juan Xing, Bao-Cai Long-term postoperative survival prediction in patients with colorectal liver metastasis |
title | Long-term postoperative survival prediction in patients with colorectal liver metastasis |
title_full | Long-term postoperative survival prediction in patients with colorectal liver metastasis |
title_fullStr | Long-term postoperative survival prediction in patients with colorectal liver metastasis |
title_full_unstemmed | Long-term postoperative survival prediction in patients with colorectal liver metastasis |
title_short | Long-term postoperative survival prediction in patients with colorectal liver metastasis |
title_sort | long-term postoperative survival prediction in patients with colorectal liver metastasis |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668107/ https://www.ncbi.nlm.nih.gov/pubmed/29108374 http://dx.doi.org/10.18632/oncotarget.20322 |
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