Mammalian γ2 AMPK regulates intrinsic heart rate

AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic AMPK exists as αβγ complexes, whose regulatory γ subunit confers energy sensor function by binding adenine nucleotides. Humans bearing activating mutations in the γ2 subunit exhibit a phenoty...

Descripción completa

Detalles Bibliográficos
Autores principales: Yavari, Arash, Bellahcene, Mohamed, Bucchi, Annalisa, Sirenko, Syevda, Pinter, Katalin, Herring, Neil, Jung, Julia J., Tarasov, Kirill V., Sharpe, Emily J., Wolfien, Markus, Czibik, Gabor, Steeples, Violetta, Ghaffari, Sahar, Nguyen, Chinh, Stockenhuber, Alexander, Clair, Joshua R. St., Rimmbach, Christian, Okamoto, Yosuke, Yang, Dongmei, Wang, Mingyi, Ziman, Bruce D., Moen, Jack M., Riordon, Daniel R., Ramirez, Christopher, Paina, Manuel, Lee, Joonho, Zhang, Jing, Ahmet, Ismayil, Matt, Michael G., Tarasova, Yelena S., Baban, Dilair, Sahgal, Natasha, Lockstone, Helen, Puliyadi, Rathi, de Bono, Joseph, Siggs, Owen M., Gomes, John, Muskett, Hannah, Maguire, Mahon L., Beglov, Youlia, Kelly, Matthew, dos Santos, Pedro P. N., Bright, Nicola J., Woods, Angela, Gehmlich, Katja, Isackson, Henrik, Douglas, Gillian, Ferguson, David J. P., Schneider, Jürgen E., Tinker, Andrew, Wolkenhauer, Olaf, Channon, Keith M., Cornall, Richard J., Sternick, Eduardo B., Paterson, David J., Redwood, Charles S., Carling, David, Proenza, Catherine, David, Robert, Baruscotti, Mirko, DiFrancesco, Dario, Lakatta, Edward G., Watkins, Hugh, Ashrafian, Houman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668267/
https://www.ncbi.nlm.nih.gov/pubmed/29097735
http://dx.doi.org/10.1038/s41467-017-01342-5

Ejemplares similares

Ejemplares similares