Phosphodiester backbone of the CpG motif within immunostimulatory oligodeoxynucleotides augments activation of Toll-like receptor 9

Toll-like receptor 9 (TLR9) stimulatory CpG-containing oligodeoxynucleotides (ODNs) with phosphorothioate backbones have successfully replaced the naturally occurring agonists of TLR9 in drug development due to their increased stability. Replacing the nonbridging oxygen with a sulfur atom in the pho...

Descripción completa

Detalles Bibliográficos
Autores principales: Pohar, Jelka, Lainšček, Duško, Kunšek, Ana, Cajnko, Miša-Mojca, Jerala, Roman, Benčina, Mojca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668283/
https://www.ncbi.nlm.nih.gov/pubmed/29097808
http://dx.doi.org/10.1038/s41598-017-15178-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668283/
https://www.ncbi.nlm.nih.gov/pubmed/29097808
http://dx.doi.org/10.1038/s41598-017-15178-y

Ejemplares similares