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Phosphodiester backbone of the CpG motif within immunostimulatory oligodeoxynucleotides augments activation of Toll-like receptor 9

Toll-like receptor 9 (TLR9) stimulatory CpG-containing oligodeoxynucleotides (ODNs) with phosphorothioate backbones have successfully replaced the naturally occurring agonists of TLR9 in drug development due to their increased stability. Replacing the nonbridging oxygen with a sulfur atom in the pho...

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Detalles Bibliográficos
Autores principales:	Pohar, Jelka, Lainšček, Duško, Kunšek, Ana, Cajnko, Miša-Mojca, Jerala, Roman, Benčina, Mojca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668283/ https://www.ncbi.nlm.nih.gov/pubmed/29097808 http://dx.doi.org/10.1038/s41598-017-15178-y

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