Determination of total and unbound docetaxel in plasma by ultrafiltration and UPLC-MS/MS: application to pharmacokinetic studies

A sensitive and specific liquid chromatographic/tandem mass spectrometric (LC-MS/MS) method was developed and validated for quantifying total and unbound docetaxel drug concentrations in plasma. Calibration curves for unbound and total docetaxel were linear over the respective ranges of 0.108~10.8 a...

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Detalles Bibliográficos
Autores principales: Sheu, Ming-Thau, Wu, Chen-Yuan, Su, Chia-Yu, Ho, Hsiu-O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668284/
https://www.ncbi.nlm.nih.gov/pubmed/29097770
http://dx.doi.org/10.1038/s41598-017-15176-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668284/
https://www.ncbi.nlm.nih.gov/pubmed/29097770
http://dx.doi.org/10.1038/s41598-017-15176-0

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