TDP-43 accelerates age-dependent degeneration of interneurons

TDP-43 is an RNA-binding protein important for many aspects of RNA metabolism. Abnormal accumulation of TDP-43 in the cytoplasm of affected neurons is a pathological hallmark of the neurodegenerative diseases frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Several transgenic m...

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Detalles Bibliográficos
Autores principales: Tsuiji, Hitomi, Inoue, Ikuyo, Takeuchi, Mari, Furuya, Asako, Yamakage, Yuko, Watanabe, Seiji, Koike, Masato, Hattori, Mitsuharu, Yamanaka, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668320/
https://www.ncbi.nlm.nih.gov/pubmed/29097807
http://dx.doi.org/10.1038/s41598-017-14966-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668320/
https://www.ncbi.nlm.nih.gov/pubmed/29097807
http://dx.doi.org/10.1038/s41598-017-14966-w

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