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A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents
Dph3 is involved in diphthamide modification of the eukaryotic translation elongation factor eEF2 and in Elongator-mediated modifications of tRNAs, where a 5-methoxycarbonyl-methyl moiety is added to wobble uridines. Lack of such modifications affects protein synthesis due to inaccurate translation...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668335/ https://www.ncbi.nlm.nih.gov/pubmed/28555368 http://dx.doi.org/10.1007/s00294-017-0711-x |