RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain

Although ubiquitin ligases have been implicated in autism, their roles and mechanisms in brain development remain incompletely understood. Here, we report that in vivo knockdown or conditional knockout of the autism-linked ubiquitin ligase RNF8 or associated ubiquitin-conjugating enzyme UBC13 in rod...

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Detalles Bibliográficos
Autores principales: Valnegri, Pamela, Huang, Ju, Yamada, Tomoko, Yang, Yue, Mejia, Luis A., Cho, Ha Y., Oldenborg, Anna, Bonni, Azad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668370/
https://www.ncbi.nlm.nih.gov/pubmed/29097665
http://dx.doi.org/10.1038/s41467-017-01333-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668370/
https://www.ncbi.nlm.nih.gov/pubmed/29097665
http://dx.doi.org/10.1038/s41467-017-01333-6

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