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Impact of random urine proteinuria on maternal and fetal outcomes of pregnancy: a retrospective case-control study
BACKGROUND/AIMS: Proteinuria is associated with hypertension and preeclampsia in pregnancy. However, the impact of random urine proteinuria on fetal and maternal outcomes has not been established. We investigated the influence of random urine proteinuria on the clinical outcomes of pregnancy. METHOD...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Internal Medicine
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668390/ https://www.ncbi.nlm.nih.gov/pubmed/27733023 http://dx.doi.org/10.3904/kjim.2016.025 |
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author | Bae, Eun Hui Kim, Jong Woon Choi, Hong Sang Ma, Seong Kwon Kim, Soo Wan |
author_facet | Bae, Eun Hui Kim, Jong Woon Choi, Hong Sang Ma, Seong Kwon Kim, Soo Wan |
author_sort | Bae, Eun Hui |
collection | PubMed |
description | BACKGROUND/AIMS: Proteinuria is associated with hypertension and preeclampsia in pregnancy. However, the impact of random urine proteinuria on fetal and maternal outcomes has not been established. We investigated the influence of random urine proteinuria on the clinical outcomes of pregnancy. METHODS: From January 2008 to December 2010, 2,822 patients were retrospectively studied. A total of 536 pregnant women with proteinuria in random urine and matched controls without proteinuria via propensity score matching were analyzed. Proteinuria was checked by the dipstick method. RESULTS: The patients’ mean age was 33.0 ± 4.7 years, and the mean gestational age was 235.6 ± 50.6 days on admission. The prevalence of hypertension and chronic kidney disease was 2.4% (n = 67) and 1.0% (n = 29), respectively. Women with random urine proteinuria showed higher blood urea nitrogen levels and a higher incidence of hematuria. These women also had a higher incidence of preeclampsia, preterm labor, premature rupture of membranes, and intrauterine growth restriction. Proteinuria was strongly correlated with preeclampsia in both propensity score matching (p < 0.001, r = 0.783) and unmatched whole samples (p < 0.001, r = 0.851). CONCLUSIONS: These findings suggest that random urine proteinuria is associated with preeclampsia, preterm labor, premature rupture of membrane, and intrauterine growth restriction. |
format | Online Article Text |
id | pubmed-5668390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-56683902017-11-13 Impact of random urine proteinuria on maternal and fetal outcomes of pregnancy: a retrospective case-control study Bae, Eun Hui Kim, Jong Woon Choi, Hong Sang Ma, Seong Kwon Kim, Soo Wan Korean J Intern Med Original Article BACKGROUND/AIMS: Proteinuria is associated with hypertension and preeclampsia in pregnancy. However, the impact of random urine proteinuria on fetal and maternal outcomes has not been established. We investigated the influence of random urine proteinuria on the clinical outcomes of pregnancy. METHODS: From January 2008 to December 2010, 2,822 patients were retrospectively studied. A total of 536 pregnant women with proteinuria in random urine and matched controls without proteinuria via propensity score matching were analyzed. Proteinuria was checked by the dipstick method. RESULTS: The patients’ mean age was 33.0 ± 4.7 years, and the mean gestational age was 235.6 ± 50.6 days on admission. The prevalence of hypertension and chronic kidney disease was 2.4% (n = 67) and 1.0% (n = 29), respectively. Women with random urine proteinuria showed higher blood urea nitrogen levels and a higher incidence of hematuria. These women also had a higher incidence of preeclampsia, preterm labor, premature rupture of membranes, and intrauterine growth restriction. Proteinuria was strongly correlated with preeclampsia in both propensity score matching (p < 0.001, r = 0.783) and unmatched whole samples (p < 0.001, r = 0.851). CONCLUSIONS: These findings suggest that random urine proteinuria is associated with preeclampsia, preterm labor, premature rupture of membrane, and intrauterine growth restriction. The Korean Association of Internal Medicine 2017-11 2016-10-13 /pmc/articles/PMC5668390/ /pubmed/27733023 http://dx.doi.org/10.3904/kjim.2016.025 Text en Copyright © 2016 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Bae, Eun Hui Kim, Jong Woon Choi, Hong Sang Ma, Seong Kwon Kim, Soo Wan Impact of random urine proteinuria on maternal and fetal outcomes of pregnancy: a retrospective case-control study |
title | Impact of random urine proteinuria on maternal and fetal outcomes of pregnancy: a retrospective case-control study |
title_full | Impact of random urine proteinuria on maternal and fetal outcomes of pregnancy: a retrospective case-control study |
title_fullStr | Impact of random urine proteinuria on maternal and fetal outcomes of pregnancy: a retrospective case-control study |
title_full_unstemmed | Impact of random urine proteinuria on maternal and fetal outcomes of pregnancy: a retrospective case-control study |
title_short | Impact of random urine proteinuria on maternal and fetal outcomes of pregnancy: a retrospective case-control study |
title_sort | impact of random urine proteinuria on maternal and fetal outcomes of pregnancy: a retrospective case-control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668390/ https://www.ncbi.nlm.nih.gov/pubmed/27733023 http://dx.doi.org/10.3904/kjim.2016.025 |
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