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LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects
BACKGROUND/AIMS: Although lipoprotein lipase (LPL) gene Pvu II polymorphism has been associated with an increased risk of hypertriglyceridemia (HT), there is no clear consensus within the scientific community. METHODS: A meta-analysis of 1,640 subjects from six individual studies was conducted to be...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Internal Medicine
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668391/ https://www.ncbi.nlm.nih.gov/pubmed/28502159 http://dx.doi.org/10.3904/kjim.2016.043 |
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author | Li, Yan-yan Zhou, Yan-hong Gong, Ge Geng, Hong-yu Yang, Xin-xing Wang, Xiang-ming Zhou, Chuan-wei Xu, Jian Qian, Yun |
author_facet | Li, Yan-yan Zhou, Yan-hong Gong, Ge Geng, Hong-yu Yang, Xin-xing Wang, Xiang-ming Zhou, Chuan-wei Xu, Jian Qian, Yun |
author_sort | Li, Yan-yan |
collection | PubMed |
description | BACKGROUND/AIMS: Although lipoprotein lipase (LPL) gene Pvu II polymorphism has been associated with an increased risk of hypertriglyceridemia (HT), there is no clear consensus within the scientific community. METHODS: A meta-analysis of 1,640 subjects from six individual studies was conducted to better elucidate the potential relationship between the LPL gene Pvu II polymorphism and HT within the Chinese population. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were evaluated by using fixed effect models. RESULTS: Our analysis indicated a significant association between LPL gene Pvu II polymorphism and HT within the Chinese population under allelic (OR, 1.550; 95% CI, 1.320 to 1.830; p = 1.158 × 10(-7)), recessive (OR, 0.540; 95% CI, 0.390 to 0.750; p = 0.0002), dominant (OR, 1.889; 95% CI, 1.501 to 2.377; p = 5.960 × 10(-8)), homozygous (OR, 2.167; 95% CI, 1.531 to 3.067; p = 1.242 × 10(-5)), heterozygous (OR, 1.810; 95% CI, 1.419 to 2.309; p = 1.842 × 10(-6)), and additive genetic models (OR, 1.553; 95% CI, 1.320 to 1.828; p = 1.158 × 10(-7)). CONCLUSIONS: Because LPL gene Pvu II restriction fragment length polymorphism polymorphism was associated with an elevated risk of HT, the P+ allele carriers of the LPL gene might be predisposed to HT. |
format | Online Article Text |
id | pubmed-5668391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-56683912017-11-13 LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects Li, Yan-yan Zhou, Yan-hong Gong, Ge Geng, Hong-yu Yang, Xin-xing Wang, Xiang-ming Zhou, Chuan-wei Xu, Jian Qian, Yun Korean J Intern Med Original Article BACKGROUND/AIMS: Although lipoprotein lipase (LPL) gene Pvu II polymorphism has been associated with an increased risk of hypertriglyceridemia (HT), there is no clear consensus within the scientific community. METHODS: A meta-analysis of 1,640 subjects from six individual studies was conducted to better elucidate the potential relationship between the LPL gene Pvu II polymorphism and HT within the Chinese population. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were evaluated by using fixed effect models. RESULTS: Our analysis indicated a significant association between LPL gene Pvu II polymorphism and HT within the Chinese population under allelic (OR, 1.550; 95% CI, 1.320 to 1.830; p = 1.158 × 10(-7)), recessive (OR, 0.540; 95% CI, 0.390 to 0.750; p = 0.0002), dominant (OR, 1.889; 95% CI, 1.501 to 2.377; p = 5.960 × 10(-8)), homozygous (OR, 2.167; 95% CI, 1.531 to 3.067; p = 1.242 × 10(-5)), heterozygous (OR, 1.810; 95% CI, 1.419 to 2.309; p = 1.842 × 10(-6)), and additive genetic models (OR, 1.553; 95% CI, 1.320 to 1.828; p = 1.158 × 10(-7)). CONCLUSIONS: Because LPL gene Pvu II restriction fragment length polymorphism polymorphism was associated with an elevated risk of HT, the P+ allele carriers of the LPL gene might be predisposed to HT. The Korean Association of Internal Medicine 2017-11 2017-05-16 /pmc/articles/PMC5668391/ /pubmed/28502159 http://dx.doi.org/10.3904/kjim.2016.043 Text en Copyright © 2017 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Li, Yan-yan Zhou, Yan-hong Gong, Ge Geng, Hong-yu Yang, Xin-xing Wang, Xiang-ming Zhou, Chuan-wei Xu, Jian Qian, Yun LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects |
title | LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects |
title_full | LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects |
title_fullStr | LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects |
title_full_unstemmed | LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects |
title_short | LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects |
title_sort | lpl gene pvu ii polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668391/ https://www.ncbi.nlm.nih.gov/pubmed/28502159 http://dx.doi.org/10.3904/kjim.2016.043 |
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