Dual targeting improves capture of ultrasound microbubbles towards activated platelets but yields no additional benefit for imaging of arterial thrombosis

Platelets can be found on the surface of inflamed and ruptured atherosclerotic plaques. Thus, targeting of activated platelets may allow for molecular imaging of vulnerable atherosclerotic lesions. We here investigated microbubbles (MB) functionalized with the selectin ligand sialyl Lewis(a) individ...

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Detalles Bibliográficos
Autores principales: Günther, F., Heidt, T., Kramer, M., Khanicheh, E., Klibanov, A. L., Geibel-Zehender, A., Ferrante, E. A., Hilgendorf, I., Wolf, D., Zirlik, A., Reinöhl, J., Bode, C., Peter, K., Kaufmann, B. A., Mühlen, C. von zur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668440/
https://www.ncbi.nlm.nih.gov/pubmed/29097799
http://dx.doi.org/10.1038/s41598-017-15080-7

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