Research progress on the relationship between zinc deficiency, related microRNAs, and esophageal carcinoma

Esophageal cancer (EC) is a common malignant tumor of the gastrointestinal tract with a high incidence in China. Zinc (Zn) deficiency is a key risk factor for the occurrence and development of EC and affects progression by regulating microRNA (miRNA, miR) expression. In addition, the dysregulation o...

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Detalles Bibliográficos
Autores principales: Liu, Cong‐Min, Liang, Di, Jin, Jing, Li, Dao‐Juan, Zhang, Ya‐Chen, Gao, Zhao‐Yu, He, Yu‐Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2017
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668500/
https://www.ncbi.nlm.nih.gov/pubmed/28892299
http://dx.doi.org/10.1111/1759-7714.12493
Descripción
Sumario:Esophageal cancer (EC) is a common malignant tumor of the gastrointestinal tract with a high incidence in China. Zinc (Zn) deficiency is a key risk factor for the occurrence and development of EC and affects progression by regulating microRNA (miRNA, miR) expression. In addition, the dysregulation of miRNAs is accompanied by the dysregulation of their target genes in EC. In this paper, we review the potential molecular mechanisms between Zn deficiency and EC with the aim of providing new strategies and methods for early diagnosis, targeted therapy, and prognostic evaluation.

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