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Logistic regression analysis of the risk factors of anastomotic fistula after radical resection of esophageal‐cardiac cancer

BACKGROUND: This study was conducted to investigate the risk factors of anastomotic fistula after the radical resection of esophageal‐cardiac cancer. METHODS: Five hundred and forty‐four esophageal‐cardiac cancer patients who underwent surgery and had complete clinical data were included in the stud...

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Autores principales: Huang, Jinxi, Zhou, Yi, Wang, Chenghu, Yuan, Weiwei, Zhang, Zhandong, Chen, Beibei, Zhang, Xiefu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668517/
https://www.ncbi.nlm.nih.gov/pubmed/28940985
http://dx.doi.org/10.1111/1759-7714.12509
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author Huang, Jinxi
Zhou, Yi
Wang, Chenghu
Yuan, Weiwei
Zhang, Zhandong
Chen, Beibei
Zhang, Xiefu
author_facet Huang, Jinxi
Zhou, Yi
Wang, Chenghu
Yuan, Weiwei
Zhang, Zhandong
Chen, Beibei
Zhang, Xiefu
author_sort Huang, Jinxi
collection PubMed
description BACKGROUND: This study was conducted to investigate the risk factors of anastomotic fistula after the radical resection of esophageal‐cardiac cancer. METHODS: Five hundred and forty‐four esophageal‐cardiac cancer patients who underwent surgery and had complete clinical data were included in the study. Fifty patients diagnosed with postoperative anastomotic fistula were considered the case group and the remaining 494 subjects who did not develop postoperative anastomotic fistula were considered the control. The potential risk factors for anastomotic fistula, such as age, gender, diabetes history, smoking history, were collected and compared between the groups. Statistically significant variables were substituted into logistic regression to further evaluate the independent risk factors for postoperative anastomotic fistulas in esophageal‐cardiac cancer. RESULTS: The incidence of anastomotic fistulas was 9.2% (50/544). Logistic regression analysis revealed that female gender (P < 0.05), laparoscopic surgery (P < 0.05), decreased postoperative albumin (P < 0.05), and postoperative renal dysfunction (P < 0.05) were independent risk factors for anastomotic fistulas in patients who received surgery for esophageal‐cardiac cancer. Of the 50 anastomotic fistulas, 16 cases were small fistulas, which were only discovered by conventional imaging examination and not presenting clinical symptoms. All of the anastomotic fistulas occurred within seven days after surgery. Five of the patients with anastomotic fistulas underwent a second surgery and three died. CONCLUSION: Female patients with esophageal‐cardiac cancer treated with endoscopic surgery and suffering from postoperative hypoproteinemia and renal dysfunction were susceptible to postoperative anastomotic fistula.
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spelling pubmed-56685172017-11-09 Logistic regression analysis of the risk factors of anastomotic fistula after radical resection of esophageal‐cardiac cancer Huang, Jinxi Zhou, Yi Wang, Chenghu Yuan, Weiwei Zhang, Zhandong Chen, Beibei Zhang, Xiefu Thorac Cancer Original Articles BACKGROUND: This study was conducted to investigate the risk factors of anastomotic fistula after the radical resection of esophageal‐cardiac cancer. METHODS: Five hundred and forty‐four esophageal‐cardiac cancer patients who underwent surgery and had complete clinical data were included in the study. Fifty patients diagnosed with postoperative anastomotic fistula were considered the case group and the remaining 494 subjects who did not develop postoperative anastomotic fistula were considered the control. The potential risk factors for anastomotic fistula, such as age, gender, diabetes history, smoking history, were collected and compared between the groups. Statistically significant variables were substituted into logistic regression to further evaluate the independent risk factors for postoperative anastomotic fistulas in esophageal‐cardiac cancer. RESULTS: The incidence of anastomotic fistulas was 9.2% (50/544). Logistic regression analysis revealed that female gender (P < 0.05), laparoscopic surgery (P < 0.05), decreased postoperative albumin (P < 0.05), and postoperative renal dysfunction (P < 0.05) were independent risk factors for anastomotic fistulas in patients who received surgery for esophageal‐cardiac cancer. Of the 50 anastomotic fistulas, 16 cases were small fistulas, which were only discovered by conventional imaging examination and not presenting clinical symptoms. All of the anastomotic fistulas occurred within seven days after surgery. Five of the patients with anastomotic fistulas underwent a second surgery and three died. CONCLUSION: Female patients with esophageal‐cardiac cancer treated with endoscopic surgery and suffering from postoperative hypoproteinemia and renal dysfunction were susceptible to postoperative anastomotic fistula. John Wiley & Sons Australia, Ltd 2017-09-20 2017-11 /pmc/articles/PMC5668517/ /pubmed/28940985 http://dx.doi.org/10.1111/1759-7714.12509 Text en © 2017 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Huang, Jinxi
Zhou, Yi
Wang, Chenghu
Yuan, Weiwei
Zhang, Zhandong
Chen, Beibei
Zhang, Xiefu
Logistic regression analysis of the risk factors of anastomotic fistula after radical resection of esophageal‐cardiac cancer
title Logistic regression analysis of the risk factors of anastomotic fistula after radical resection of esophageal‐cardiac cancer
title_full Logistic regression analysis of the risk factors of anastomotic fistula after radical resection of esophageal‐cardiac cancer
title_fullStr Logistic regression analysis of the risk factors of anastomotic fistula after radical resection of esophageal‐cardiac cancer
title_full_unstemmed Logistic regression analysis of the risk factors of anastomotic fistula after radical resection of esophageal‐cardiac cancer
title_short Logistic regression analysis of the risk factors of anastomotic fistula after radical resection of esophageal‐cardiac cancer
title_sort logistic regression analysis of the risk factors of anastomotic fistula after radical resection of esophageal‐cardiac cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668517/
https://www.ncbi.nlm.nih.gov/pubmed/28940985
http://dx.doi.org/10.1111/1759-7714.12509
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