In Vivo Translatome Profiling in Spinal Muscular Atrophy Reveals a Role for SMN Protein in Ribosome Biology

Genetic alterations impacting ubiquitously expressed proteins involved in RNA metabolism often result in neurodegenerative conditions, with increasing evidence suggesting that translation defects can contribute to disease. Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels...

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Detalles Bibliográficos
Autores principales: Bernabò, Paola, Tebaldi, Toma, Groen, Ewout J.N., Lane, Fiona M., Perenthaler, Elena, Mattedi, Francesca, Newbery, Helen J., Zhou, Haiyan, Zuccotti, Paola, Potrich, Valentina, Shorrock, Hannah K., Muntoni, Francesco, Quattrone, Alessandro, Gillingwater, Thomas H., Viero, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668566/
https://www.ncbi.nlm.nih.gov/pubmed/29069603
http://dx.doi.org/10.1016/j.celrep.2017.10.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668566/
https://www.ncbi.nlm.nih.gov/pubmed/29069603
http://dx.doi.org/10.1016/j.celrep.2017.10.010

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