Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects

Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding its role in tumorigenesis, the effects of FH loss on mitochondrial metabolism are still unclear. Here, we used mouse and human cell lines to...

Descripción completa

Detalles Bibliográficos
Autores principales: Tyrakis, Petros A., Yurkovich, Marie E., Sciacovelli, Marco, Papachristou, Evangelia K., Bridges, Hannah R., Gaude, Edoardo, Schreiner, Alexander, D’Santos, Clive, Hirst, Judy, Hernandez-Fernaud, Juan, Springett, Roger, Griffiths, John R., Frezza, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668630/
https://www.ncbi.nlm.nih.gov/pubmed/29069586
http://dx.doi.org/10.1016/j.celrep.2017.09.092

Ejemplares similares

Ejemplares similares