Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression

The cell of origin of pancreatic ductal adenocarcinoma (PDAC) has been controversial. Here, we show that identical oncogenic drivers trigger PDAC originating from both ductal and acinar cells with similar histology but with distinct pathophysiology and marker expression dependent on cell of origin....

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Detalles Bibliográficos
Autores principales: Ferreira, Rute M.M., Sancho, Rocio, Messal, Hendrik A., Nye, Emma, Spencer-Dene, Bradley, Stone, Richard K., Stamp, Gordon, Rosewell, Ian, Quaglia, Alberto, Behrens, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668631/
https://www.ncbi.nlm.nih.gov/pubmed/29069604
http://dx.doi.org/10.1016/j.celrep.2017.09.093

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