Insights into the inhibitory mechanism of triazole-based small molecules on phosphatidylinositol-4,5-bisphosphate binding pleckstrin homology domain

BACKGROUND: Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] is an important regulator of several cellular processes and a precursor for other second messengers which are involved in cell signaling pathways. Signaling proteins preferably interact with PI(4,5)P(2) through its pleckstrin homology (...

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Detalles Bibliográficos
Autores principales: Gorai, Sukhamoy, Bagdi, Prasanta Ray, Borah, Rituparna, Paul, Debasish, Santra, Manas Kumar, Khan, Abu Taleb, Manna, Debasis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668642/
https://www.ncbi.nlm.nih.gov/pubmed/29124147
http://dx.doi.org/10.1016/j.bbrep.2015.05.007

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