The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops

HIV-1 protease (PR) is a 99 amino acid protein responsible for proteolytic processing of the viral polyprotein – an essential step in the HIV-1 life cycle. Drug resistance mutations in PR that are selected during antiretroviral therapy lead to reduced efficacy of protease inhibitors (PI) including d...

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Detalles Bibliográficos
Autores principales: Kuiper, Benjamin D., Keusch, Bradley J., Dewdney, Tamaria G., Chordia, Poorvi, Ross, Kyla, Brunzelle, Joseph S., Kovari, Iulia A., MacArthur, Rodger, Salimnia, Hossein, Kovari, Ladislau C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668655/
https://www.ncbi.nlm.nih.gov/pubmed/29124158
http://dx.doi.org/10.1016/j.bbrep.2015.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668655/
https://www.ncbi.nlm.nih.gov/pubmed/29124158
http://dx.doi.org/10.1016/j.bbrep.2015.06.003

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