Cargando…

The association between physical activity and atrial fibrillation applying the Heaviside function in survival analysis: the Multi-Ethnic Study of Atherosclerosis

OBJECTIVES: Although the effect of physical activity (PA) on the incidence of atrial fibrillation (AF) has been studied, contradictory results have been reported. Such discrepancies may reflect the different effects of various types of PA upon AF, as well as gender interactions. Therefore, we aimed...

Descripción completa

Detalles Bibliográficos
Autores principales: Mokhayeri, Yaser, Hashemi-Nazari, Seyed Saeed, Mansournia, Mohammad Ali, Soori, Hamid, Khodakarim, Soheila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Epidemiology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668664/
https://www.ncbi.nlm.nih.gov/pubmed/28728352
http://dx.doi.org/10.4178/epih.e2017024
_version_ 1783275708413378560
author Mokhayeri, Yaser
Hashemi-Nazari, Seyed Saeed
Mansournia, Mohammad Ali
Soori, Hamid
Khodakarim, Soheila
author_facet Mokhayeri, Yaser
Hashemi-Nazari, Seyed Saeed
Mansournia, Mohammad Ali
Soori, Hamid
Khodakarim, Soheila
author_sort Mokhayeri, Yaser
collection PubMed
description OBJECTIVES: Although the effect of physical activity (PA) on the incidence of atrial fibrillation (AF) has been studied, contradictory results have been reported. Such discrepancies may reflect the different effects of various types of PA upon AF, as well as gender interactions. Therefore, we aimed to evaluate the associations of PA types (total, moderate/vigorous, and intentional), as well as walking pace, with AF risk in men and women. METHODS: Using the Multi-Ethnic Study of Atherosclerosis Typical Week Physical Activity Survey, 3 PA measures and walking pace were calculated among 6,487 men and women aged 45-84 years. The incidence of AF over approximately 11 years of follow-up was ascertained. The association of each PA measure and walking pace with AF incidence was estimated using multivariable Cox proportional hazard models. An extended Cox model with Heaviside functions (hv) of time was used to estimate the effects of time-varying covariates. RESULTS: During 11 years of follow-up (49,557 person-years), 242 new AF cases occurred. The incidence rate of AF was 48.83 per 10,000 person-years. The proportional hazard (PH) assumption for total PA among women was not met; hence, we used the hv to calculate the hazard ratio. Total PA in women in the hv2 analysis was negatively associated with AF in all 3 models, although for hv1 no significant association was observed. The PH assumption for walking pace among men was not met, and none of the hv showed a statistically significant association between walking pace and AF in men. CONCLUSIONS: These results suggest that PA is inversely associated with AF in women.
format Online
Article
Text
id pubmed-5668664
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Korean Society of Epidemiology
record_format MEDLINE/PubMed
spelling pubmed-56686642017-11-20 The association between physical activity and atrial fibrillation applying the Heaviside function in survival analysis: the Multi-Ethnic Study of Atherosclerosis Mokhayeri, Yaser Hashemi-Nazari, Seyed Saeed Mansournia, Mohammad Ali Soori, Hamid Khodakarim, Soheila Epidemiol Health Original Article OBJECTIVES: Although the effect of physical activity (PA) on the incidence of atrial fibrillation (AF) has been studied, contradictory results have been reported. Such discrepancies may reflect the different effects of various types of PA upon AF, as well as gender interactions. Therefore, we aimed to evaluate the associations of PA types (total, moderate/vigorous, and intentional), as well as walking pace, with AF risk in men and women. METHODS: Using the Multi-Ethnic Study of Atherosclerosis Typical Week Physical Activity Survey, 3 PA measures and walking pace were calculated among 6,487 men and women aged 45-84 years. The incidence of AF over approximately 11 years of follow-up was ascertained. The association of each PA measure and walking pace with AF incidence was estimated using multivariable Cox proportional hazard models. An extended Cox model with Heaviside functions (hv) of time was used to estimate the effects of time-varying covariates. RESULTS: During 11 years of follow-up (49,557 person-years), 242 new AF cases occurred. The incidence rate of AF was 48.83 per 10,000 person-years. The proportional hazard (PH) assumption for total PA among women was not met; hence, we used the hv to calculate the hazard ratio. Total PA in women in the hv2 analysis was negatively associated with AF in all 3 models, although for hv1 no significant association was observed. The PH assumption for walking pace among men was not met, and none of the hv showed a statistically significant association between walking pace and AF in men. CONCLUSIONS: These results suggest that PA is inversely associated with AF in women. Korean Society of Epidemiology 2017-06-18 /pmc/articles/PMC5668664/ /pubmed/28728352 http://dx.doi.org/10.4178/epih.e2017024 Text en ©2017, Korean Society of Epidemiology This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mokhayeri, Yaser
Hashemi-Nazari, Seyed Saeed
Mansournia, Mohammad Ali
Soori, Hamid
Khodakarim, Soheila
The association between physical activity and atrial fibrillation applying the Heaviside function in survival analysis: the Multi-Ethnic Study of Atherosclerosis
title The association between physical activity and atrial fibrillation applying the Heaviside function in survival analysis: the Multi-Ethnic Study of Atherosclerosis
title_full The association between physical activity and atrial fibrillation applying the Heaviside function in survival analysis: the Multi-Ethnic Study of Atherosclerosis
title_fullStr The association between physical activity and atrial fibrillation applying the Heaviside function in survival analysis: the Multi-Ethnic Study of Atherosclerosis
title_full_unstemmed The association between physical activity and atrial fibrillation applying the Heaviside function in survival analysis: the Multi-Ethnic Study of Atherosclerosis
title_short The association between physical activity and atrial fibrillation applying the Heaviside function in survival analysis: the Multi-Ethnic Study of Atherosclerosis
title_sort association between physical activity and atrial fibrillation applying the heaviside function in survival analysis: the multi-ethnic study of atherosclerosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668664/
https://www.ncbi.nlm.nih.gov/pubmed/28728352
http://dx.doi.org/10.4178/epih.e2017024
work_keys_str_mv AT mokhayeriyaser theassociationbetweenphysicalactivityandatrialfibrillationapplyingtheheavisidefunctioninsurvivalanalysisthemultiethnicstudyofatherosclerosis
AT hasheminazariseyedsaeed theassociationbetweenphysicalactivityandatrialfibrillationapplyingtheheavisidefunctioninsurvivalanalysisthemultiethnicstudyofatherosclerosis
AT mansourniamohammadali theassociationbetweenphysicalactivityandatrialfibrillationapplyingtheheavisidefunctioninsurvivalanalysisthemultiethnicstudyofatherosclerosis
AT soorihamid theassociationbetweenphysicalactivityandatrialfibrillationapplyingtheheavisidefunctioninsurvivalanalysisthemultiethnicstudyofatherosclerosis
AT khodakarimsoheila theassociationbetweenphysicalactivityandatrialfibrillationapplyingtheheavisidefunctioninsurvivalanalysisthemultiethnicstudyofatherosclerosis
AT mokhayeriyaser associationbetweenphysicalactivityandatrialfibrillationapplyingtheheavisidefunctioninsurvivalanalysisthemultiethnicstudyofatherosclerosis
AT hasheminazariseyedsaeed associationbetweenphysicalactivityandatrialfibrillationapplyingtheheavisidefunctioninsurvivalanalysisthemultiethnicstudyofatherosclerosis
AT mansourniamohammadali associationbetweenphysicalactivityandatrialfibrillationapplyingtheheavisidefunctioninsurvivalanalysisthemultiethnicstudyofatherosclerosis
AT soorihamid associationbetweenphysicalactivityandatrialfibrillationapplyingtheheavisidefunctioninsurvivalanalysisthemultiethnicstudyofatherosclerosis
AT khodakarimsoheila associationbetweenphysicalactivityandatrialfibrillationapplyingtheheavisidefunctioninsurvivalanalysisthemultiethnicstudyofatherosclerosis